Details for: TRDD3

Gene ID: 28523

Symbol: TRDD3

Ensembl ID: ENSG00000228985

Description: T cell receptor delta diversity 3

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.2304
    Cell Significance Index: 3.7300
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0.0311
    Cell Significance Index: 0.3300
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.0202
    Cell Significance Index: 0.2600
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0126
    Cell Significance Index: -0.1800
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0226
    Cell Significance Index: -0.3000
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0763
    Cell Significance Index: -1.9400
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0943
    Cell Significance Index: -1.6100
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.1880
    Cell Significance Index: -2.5800
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.2127
    Cell Significance Index: -2.8000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The TRDD3 gene is a member of the T cell receptor delta (TRD) family, which is essential for the development and function of T cells. The TRDD3 gene encodes a protein that is involved in the regulation of immune cell development, proliferation, and differentiation. The gene is highly expressed in cells of the immune system, including natural killer cells, mast cells, and decidual natural killer cells, which are involved in the regulation of immune responses during pregnancy. The TRDD3 gene is also expressed in hematopoietic stem cells, megakaryocytes, and precursor B cells, indicating its role in the development of multiple immune cell types. **Pathways and Functions:** The TRDD3 gene is involved in several signaling pathways that regulate immune cell development and function. The TRD family, to which TRDD3 belongs, is known to interact with other immune receptors, such as the T cell receptor (TCR) and the killer cell immunoglobulin-like receptors (KIRs). The interaction between TRDD3 and these receptors is thought to modulate the activity of immune cells, influencing their proliferation, differentiation, and survival. Additionally, TRDD3 has been shown to interact with other signaling molecules, such as Janus kinase (JAK) and phosphatidylinositol 3-kinase (PI3K), which are involved in the regulation of immune cell function. The functions of TRDD3 are multifaceted, and its dysregulation has been implicated in various immune-related disorders. TRDD3 is involved in the regulation of immune cell development, including the differentiation of natural killer cells and T cells. It also plays a role in the regulation of immune responses during pregnancy, where decidual natural killer cells express TRDD3 to modulate the immune response and prevent rejection of the fetus. Furthermore, TRDD3 has been shown to be involved in the regulation of hematopoiesis, influencing the development of megakaryocytes and precursor B cells. **Clinical Significance:** The dysregulation of TRDD3 has been implicated in various immune-related disorders, including autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. Alterations in TRDD3 expression have also been observed in cancer, where it is thought to contribute to the development and progression of tumors. Additionally, TRDD3 has been shown to play a role in the regulation of immune responses during pregnancy, and alterations in TRDD3 expression have been associated with recurrent miscarriage and other pregnancy-related complications. In conclusion, the TRDD3 gene is a critical component of the immune system, playing a pivotal role in the development and function of various immune cells. The diverse expression patterns of TRDD3 suggest its involvement in multiple cellular processes, including cell differentiation, proliferation, and survival. Further research is needed to fully understand the functions of TRDD3 and its clinical significance in immune-related disorders.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.