Details for: IGLV3 17

Gene ID: 28798

Symbol: IGLV3 17

Ensembl ID: ENSG00000253152

Description: immunoglobulin lambda variable 3-17 (pseudogene)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0087
    Cell Significance Index: -0.1600
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0141
    Cell Significance Index: -0.3600
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0174
    Cell Significance Index: -0.1900
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0262
    Cell Significance Index: -0.3400
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0296
    Cell Significance Index: -0.3100
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0324
    Cell Significance Index: -0.3300
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0364
    Cell Significance Index: -0.4300
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.0366
    Cell Significance Index: -0.3200
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.0393
    Cell Significance Index: -0.4500
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0423
    Cell Significance Index: -0.4000
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.0495
    Cell Significance Index: -0.3900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Pseudogene status**: IGLV3-17 is classified as a pseudogene, which implies that it has undergone significant degradation or silencing, resulting in a non-functional gene product. This distinction is essential, as pseudogenes often serve as "decoys" for gene regulation and can influence gene expression through epigenetic mechanisms. 2. **Widespread expression**: IGLV3-17 is expressed in multiple cell types, including plasma cells, B cells, CD8-positive T cells, and mature alpha-beta T cells. This pan-expression profile suggests that the gene may play a role in regulating immune responses across different cell subsets. 3. **Lack of functional significance**: Despite its widespread expression, IGLV3-17 has not been directly linked to any known functional roles or immune-related pathways. This absence of functional significance raises questions about the gene's utility and potential impact on immune function. **Pathways and Functions:** 1. **Immunoglobulin gene regulation**: IGLV3-17 may play a role in regulating the expression of immunoglobulin genes, particularly in T cells. The gene's presence in mature alpha-beta T cells could influence T cell receptor (TCR) expression and function, potentially modulating immune responses. 2. **T cell tolerance and regulation**: The expression of IGLV3-17 in CD8-positive T cells may contribute to the development of T cell tolerance, a process by which the immune system learns to distinguish between self and non-self antigens. This could have implications for the prevention of autoimmune diseases. 3. **Gene regulation by epigenetic mechanisms**: As a pseudogene, IGLV3-17 may influence gene expression through epigenetic mechanisms, such as DNA methylation or histone modification. This could have far-reaching consequences for gene regulation and immune function. **Clinical Significance:** 1. **Autoimmune disease susceptibility**: The expression of IGLV3-17 in T cells may contribute to the development of autoimmune diseases, such as multiple sclerosis or type 1 diabetes. Further research is needed to elucidate the gene's role in autoimmune disease pathogenesis. 2. **Cancer immunotherapy**: The presence of IGLV3-17 in T cells could influence the efficacy of cancer immunotherapies, which rely on the activation and expansion of antigen-specific T cells. A better understanding of the gene's role in T cell regulation may lead to the development of novel therapeutic strategies. 3. **Immunological tolerance and regulation**: The study of IGLV3-17 may provide insights into the mechanisms of immunological tolerance and regulation, with potential implications for the prevention and treatment of autoimmune diseases. In conclusion, the IGLV3-17 gene, despite its pseudogene status, has garnered attention for its widespread expression across various cell types. Further research is necessary to elucidate the gene's functional significance and its potential impact on immune function, with far-reaching implications for our understanding of autoimmune disease, cancer immunotherapy, and immunological tolerance.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.