Details for: MIR193A

Gene ID: 406968

Symbol: MIR193A

Ensembl ID: ENSG00000207614

Description: microRNA 193a

Associated with

  • Dna damage response
    (GO:0006974)
  • Extracellular vesicle
    (GO:1903561)
  • Mirna-mediated gene silencing by mrna destabilization
    (GO:0035279)
  • Mirna-mediated post-transcriptional gene silencing
    (GO:0035195)
  • Mrna 3'-utr binding
    (GO:0003730)
  • Mrna base-pairing translational repressor activity
    (GO:1903231)
  • Negative regulation of angiogenesis
    (GO:0016525)
  • Negative regulation of blood vessel endothelial cell migration
    (GO:0043537)
  • Negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
    (GO:1903588)
  • Negative regulation of cell migration involved in sprouting angiogenesis
    (GO:0090051)
  • Negative regulation of g1/s transition of mitotic cell cycle
    (GO:2000134)
  • Negative regulation of vascular endothelial cell proliferation
    (GO:1905563)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0756
    Cell Significance Index: 8.6700
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.0031
    Cell Significance Index: 0.0300
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.0010
    Cell Significance Index: 0.0100
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0018
    Cell Significance Index: -0.0200
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0027
    Cell Significance Index: -0.0300
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -0.0030
    Cell Significance Index: -0.0300
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.0038
    Cell Significance Index: -0.0300
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.0387
    Cell Significance Index: -0.5300
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.1083
    Cell Significance Index: -1.1800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1244
    Cell Significance Index: -2.7200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** MIR193A shares several key characteristics that distinguish it from other microRNAs. Firstly, its expression is highly tissue-specific, with significant expression in various cell types, including those involved in the immune system. Secondly, MIR193A has been shown to target multiple mRNAs, including those involved in angiogenesis, cell migration, and proliferation. This suggests that MIR193A may act as a key regulator of cellular processes, modulating the expression of multiple target genes. Thirdly, MIR193A has been shown to bind to specific sequences in the 3'-untranslated regions (3'-UTRs) of target mRNAs, leading to their degradation or inhibition of translation. This post-transcriptional regulation mechanism allows MIR193A to fine-tune the expression of target genes, modulating cellular processes in response to changing environmental conditions. **Pathways and Functions** MIR193A has been implicated in several cellular pathways, including: 1. **DNA Damage Response**: MIR193A has been shown to regulate the expression of genes involved in DNA damage response, including those involved in repairing DNA damage and inducing cell cycle arrest. 2. **Extracellular Vesicle Regulation**: MIR193A has been implicated in regulating the expression of genes involved in extracellular vesicle formation and function. 3. **Mirna-mediated Gene Silencing**: MIR193A has been shown to regulate the expression of target genes through mirna-mediated gene silencing, a process in which MIR193A binds to specific sequences in target mRNAs, leading to their degradation or inhibition of translation. 4. **Negative Regulation of Angiogenesis**: MIR193A has been shown to regulate the expression of genes involved in angiogenesis, including those involved in endothelial cell migration and proliferation. 5. **Negative Regulation of Blood Vessel Endothelial Cell Proliferation**: MIR193A has been implicated in regulating the expression of genes involved in blood vessel endothelial cell proliferation, a process critical for angiogenesis. **Clinical Significance** The clinical significance of MIR193A is an area of ongoing research. However, its role in regulating cellular processes, including angiogenesis and cell migration, suggests that MIR193A may play a critical role in the development and progression of various diseases, including cancer, cardiovascular disease, and neurological disorders. Furthermore, MIR193A has been implicated in the regulation of immune responses, including those involved in inflammation and autoimmune diseases. Its role in regulating the expression of genes involved in immune cell function, including those involved in T-cell activation and proliferation, suggests that MIR193A may be a potential therapeutic target for the treatment of immune-related disorders. In conclusion, MIR193A is a small non-coding RNA that plays a critical role in regulating various cellular processes, including angiogenesis, cell migration, and proliferation. Its clinical significance is an area of ongoing research, and its potential as a therapeutic target for the treatment of various diseases makes it an exciting area of study.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.