Details for: MIR195

Gene ID: 406971

Symbol: MIR195

Ensembl ID: ENSG00000284112

Description: microRNA 195

Associated with

  • Cardiac muscle hypertrophy
    (GO:0003300)
  • Cardiac muscle tissue growth involved in heart morphogenesis
    (GO:0003245)
  • Cell growth involved in cardiac muscle cell development
    (GO:0061049)
  • Lncrna binding
    (GO:0106222)
  • Mirna-mediated gene silencing by mrna destabilization
    (GO:0035279)
  • Mirna-mediated post-transcriptional gene silencing
    (GO:0035195)
  • Mrna 3'-utr binding
    (GO:0003730)
  • Mrna base-pairing translational repressor activity
    (GO:1903231)
  • Negative regulation of bmp signaling pathway
    (GO:0030514)
  • Negative regulation of canonical nf-kappab signal transduction
    (GO:0043124)
  • Negative regulation of cell population proliferation
    (GO:0008285)
  • Negative regulation of cellular response to insulin stimulus
    (GO:1900077)
  • Negative regulation of fibroblast growth factor production
    (GO:0090272)
  • Negative regulation of g2/m transition of mitotic cell cycle
    (GO:0010972)
  • Negative regulation of glycogen biosynthetic process
    (GO:0045719)
  • Negative regulation of insulin receptor signaling pathway
    (GO:0046627)
  • Negative regulation of interleukin-1 beta production
    (GO:0032691)
  • Negative regulation of interleukin-6 production
    (GO:0032715)
  • Negative regulation of mitotic cell cycle
    (GO:0045930)
  • Negative regulation of neuroinflammatory response
    (GO:0150079)
  • Negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
    (GO:1903377)
  • Negative regulation of smad protein signal transduction
    (GO:0060392)
  • Negative regulation of tumor necrosis factor production
    (GO:0032720)
  • Negative regulation of vascular endothelial growth factor production
    (GO:1904046)
  • Positive regulation of apoptotic process
    (GO:0043065)
  • Positive regulation of cardiac muscle cell apoptotic process
    (GO:0010666)
  • Positive regulation of connective tissue replacement
    (GO:1905205)
  • Regulation of extracellular matrix disassembly
    (GO:0010715)
  • Regulation of glucosylceramide catabolic process
    (GO:2000752)
  • Response to ischemia
    (GO:0002931)
  • Risc complex
    (GO:0016442)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cerebellar neuron (CL1001611)
    Fold Change: -0.0058
    Cell Significance Index: -0.0400
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0073
    Cell Significance Index: -0.0800
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0074
    Cell Significance Index: -0.0700
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0079
    Cell Significance Index: -0.1000
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0085
    Cell Significance Index: -0.1200
  • Cell Name: brain vascular cell (CL4023072)
    Fold Change: -0.0088
    Cell Significance Index: -0.1000
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0092
    Cell Significance Index: -0.1200
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0094
    Cell Significance Index: -0.1100
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0096
    Cell Significance Index: -0.1100
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0103
    Cell Significance Index: -0.1100
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.0125
    Cell Significance Index: -0.1500
  • Cell Name: basket cell (CL0000118)
    Fold Change: -0.0228
    Cell Significance Index: -0.1100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Small non-coding RNA**: MIR195 is a microRNA, a class of small non-coding RNAs that regulate gene expression through post-transcriptional mechanisms. 2. **Cardiac-specific expression**: MIR195 is significantly expressed in cardiac muscle cells, including myoblasts, endothelial cells, and fibroblasts. 3. **Regulatory function**: MIR195 regulates various cellular processes, including cell growth, differentiation, and survival, through its interactions with target mRNAs. **Pathways and Functions:** 1. **Cardiac muscle development and hypertrophy**: MIR195 regulates the development and growth of cardiac muscle cells, including the suppression of cell proliferation and differentiation. 2. **Cell growth and proliferation**: MIR195 negatively regulates cell growth and proliferation in cardiac muscle cells, fibroblasts, and other cell types. 3. **Apoptosis and cell death**: MIR195 promotes apoptosis (programmed cell death) in cardiac muscle cells, which is essential for maintaining cardiac homeostasis. 4. **Signaling pathways**: MIR195 negatively regulates various signaling pathways, including the BMP, NF-κB, and insulin receptor signaling pathways. 5. **Cellular stress responses**: MIR195 regulates cellular responses to stress, including oxidative stress, ischemia, and inflammation. **Clinical Significance:** 1. **Cardiovascular disease**: MIR195 has been implicated in various cardiovascular diseases, including heart failure, coronary artery disease, and cardiac arrhythmias. 2. **Hypertension**: MIR195 has been shown to be overexpressed in hypertensive patients, suggesting its potential role in the development of hypertension. 3. **Cardiac remodeling**: MIR195 has been implicated in cardiac remodeling, a process by which the heart adapts to changes in blood pressure and cardiac load. 4. **Cancer**: MIR195 has been shown to be overexpressed in various types of cancer, including lung, breast, and colon cancer, suggesting its potential role in cancer development and progression. In conclusion, MIR195 is a critical regulator of cardiac health and disease, with implications for the development of cardiovascular disease, cancer, and other conditions. Further research is needed to fully understand the mechanisms by which MIR195 regulates cardiac function and disease, and to explore its potential as a therapeutic target for the treatment of cardiovascular diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.