Details for: TRBV25OR9 2

Gene ID: 6960

Symbol: TRBV25OR9 2

Ensembl ID: ENSG00000240215

Description: T cell receptor beta variable 25/OR9-2 (pseudogene)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0085
    Cell Significance Index: -0.2100
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0107
    Cell Significance Index: -0.1700
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.0143
    Cell Significance Index: -0.1500
  • Cell Name: platelet (CL0000233)
    Fold Change: -0.0145
    Cell Significance Index: -0.1500
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.0192
    Cell Significance Index: -0.2100
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0213
    Cell Significance Index: -0.2000
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.0226
    Cell Significance Index: -0.2100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Pseudogene status:** TRBV25OR9-2 is a pseudogene, meaning it lacks the ability to encode a functional protein. However, its expression is widespread, suggesting that it may play a role in regulating gene expression or influencing cellular behavior. 2. **Cell-type specificity:** The gene is significantly expressed in platelets, vascular-associated smooth muscle cells, megakaryocytes, stromal cells, neurons, pancreatic acinar cells, and near-projecting glutamatergic cortical neurons. This specificity is intriguing, as these cell types are often associated with distinct physiological and pathological processes. 3. **Evolutionary conservation:** The TRBV25OR9-2 gene is conserved across species, indicating that it may have evolved to play a crucial role in maintaining cellular homeostasis or regulating immune responses. **Pathways and Functions:** While the exact mechanisms by which TRBV25OR9-2 regulates cellular behavior are unclear, several pathways are likely involved: 1. **Gene regulation:** TRBV25OR9-2 may act as a transcriptional regulator, influencing the expression of genes involved in cellular differentiation, survival, or migration. 2. **Cell signaling:** The gene may be involved in signaling pathways that regulate cellular responses to environmental cues, such as cytokines, growth factors, or neurotransmitters. 3. **Immune modulation:** As a pseudogene, TRBV25OR9-2 may modulate immune responses, potentially influencing the development or function of immune cells, such as T cells or dendritic cells. **Clinical Significance:** The widespread expression of TRBV25OR9-2 across diverse cell types raises several questions about its clinical significance: 1. **Cancer association:** The gene's presence in cancer cells, such as megakaryocytes and stromal cells, suggests that it may play a role in tumor development or progression. 2. **Neurological disorders:** The expression of TRBV25OR9-2 in neurons and near-projecting glutamatergic cortical neurons implies that it may be involved in neurological disorders, such as Alzheimer's disease or Parkinson's disease. 3. **Inflammatory diseases:** The gene's presence in vascular-associated smooth muscle cells and stromal cells suggests that it may contribute to inflammatory diseases, such as atherosclerosis or arthritis. In conclusion, the TRBV25OR9-2 gene is a pseudogene with far-reaching implications for our understanding of cellular biology and disease. Further research is necessary to elucidate the mechanisms by which this enigmatic gene regulates cellular behavior and to explore its clinical significance in various diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.