TERC | ENSG00000277925 | NCBI 7012

Details for: TERC

Gene ID: 7012

Symbol: TERC

Ensembl ID: ENSG00000277925

Description: telomerase RNA component

Associated with

Box h/aca telomerase rnp complex
(GO:0090661)
Cajal body
(GO:0015030)
Cellular response to hypoxia
(GO:0071456)
Chromosome, telomeric region
(GO:0000781)
Cytoplasm
(GO:0005737)
Dna polymerase binding
(GO:0070182)
Negative regulation of cellular senescence
(GO:2000773)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Rna-directed dna polymerase activity
(GO:0003964)
Telomerase activity
(GO:0003720)
Telomerase catalytic core complex
(GO:0000333)
Telomerase holoenzyme complex
(GO:0005697)
Telomere maintenance via telomerase
(GO:0007004)
Template for synthesis of g-rich strand of telomere dna activity
(GO:0000332)
Wd40-repeat domain binding
(GO:0071987)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: retinal rod cell (CL0000604)
Fold Change: 0.0098
Cell Significance Index: 0.1200
Cell Name: retina horizontal cell (CL0000745)
Fold Change: -0.0044
Cell Significance Index: -0.0600
Cell Name: retinal bipolar neuron (CL0000748)
Fold Change: -0.0044
Cell Significance Index: -0.0500
Cell Name: myeloid cell (CL0000763)
Fold Change: -0.0046
Cell Significance Index: -0.0600
Cell Name: retinal ganglion cell (CL0000740)
Fold Change: -0.0065
Cell Significance Index: -0.0500
Cell Name: retinal pigment epithelial cell (CL0002586)
Fold Change: -0.0074
Cell Significance Index: -0.0800
Cell Name: retinal cone cell (CL0000573)
Fold Change: -0.0090
Cell Significance Index: -0.1100
Cell Name: amacrine cell (CL0000561)
Fold Change: -0.0099
Cell Significance Index: -0.1200
Cell Name: astrocyte (CL0000127)
Fold Change: -0.0114
Cell Significance Index: -0.1300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Other Information

Description

**Key Characteristics:** TERC is a non-coding RNA molecule that is approximately 165 nucleotides in length. It is highly conserved across species, with high sequence identity between human and mouse TERC. TERC is synthesized by the enzyme telomerase reverse transcriptase (TRT) and is the template for the synthesis of telomeres. It is also involved in the regulation of cellular senescence, a state of permanent cell cycle arrest that occurs in response to telomere shortening. **Pathways and Functions:** TERC is involved in several cellular pathways, including: 1. **Telomere Maintenance:** TERC is the template for the synthesis of telomeres, which are essential for maintaining chromosomal stability and preventing telomere shortening. 2. **Cellular Senescence:** TERC is involved in the regulation of cellular senescence, a state of permanent cell cycle arrest that occurs in response to telomere shortening. 3. **DNA Repair:** TERC is involved in the repair of DNA double-strand breaks through homologous recombination. 4. **Apoptosis:** TERC is involved in the regulation of apoptosis, a process of programmed cell death that occurs in response to cellular stress. **Clinical Significance:** Dysregulation of TERC has been implicated in various human diseases, including: 1. **Cancer:** Telomere shortening is a hallmark of cancer, and dysregulation of TERC has been associated with various types of cancer, including breast, lung, and colon cancer. 2. **Aging:** Telomere shortening is a key mechanism of aging, and dysregulation of TERC has been associated with age-related diseases, including cardiovascular disease and Alzheimer's disease. 3. **Neurodegenerative Diseases:** Telomere shortening has been implicated in neurodegenerative diseases, including Parkinson's disease and Huntington's disease. 4. **Immune System Disorders:** Dysregulation of TERC has been associated with immune system disorders, including autoimmune diseases and immunodeficiency syndromes. In conclusion, TERC is a crucial regulator of telomere length and cellular senescence. Its dysregulation has been implicated in various human diseases, including cancer, aging, neurodegenerative diseases, and immune system disorders. Further research is needed to fully understand the role of TERC in human disease and to develop therapeutic strategies to target this gene in the prevention and treatment of these diseases.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.