Gene TERC - ENSG00000277925 | NCBI Gene ID: 7012

Details for: TERC

Gene ID: 7012

Symbol: TERC

Ensembl ID: ENSG00000277925

Description: telomerase RNA component

Associated with

Box h/aca telomerase rnp complex
(GO:0090661)
Cajal body
(GO:0015030)
Cellular response to hypoxia
(GO:0071456)
Chromosome, telomeric region
(GO:0000781)
Cytoplasm
(GO:0005737)
Dna polymerase binding
(GO:0070182)
Negative regulation of cellular senescence
(GO:2000773)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Rna-directed dna polymerase activity
(GO:0003964)
Telomerase activity
(GO:0003720)
Telomerase catalytic core complex
(GO:0000333)
Telomerase holoenzyme complex
(GO:0005697)
Telomerase rna reverse transcriptase activity
(GO:0003721)
Telomere maintenance via telomerase
(GO:0007004)
Template for synthesis of g-rich strand of telomere dna activity
(GO:0000332)
Wd40-repeat domain binding
(GO:0071987)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: neuronal receptor cell (CL0000006)
Fold Change: 3.27
Marker Score: 1446
Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 2.83
Marker Score: 1348
Cell Name: pericyte (CL0000669)
Fold Change: 2.54
Marker Score: 1486
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 1.9
Marker Score: 1143
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 1.77
Marker Score: 3356.5
Cell Name: plasma cell (CL0000786)
Fold Change: 1.37
Marker Score: 1526
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.87
Marker Score: 1778.5
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.8
Marker Score: 12500.5
Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 0.69
Marker Score: 4167.5
Cell Name: retinal rod cell (CL0000604)
Fold Change: 0.55
Marker Score: 1574

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Other Information

Description

**Key Characteristics:** TERC is a non-coding RNA molecule that is approximately 165 nucleotides in length. It is highly conserved across species, with high sequence identity between human and mouse TERC. TERC is synthesized by the enzyme telomerase reverse transcriptase (TRT) and is the template for the synthesis of telomeres. It is also involved in the regulation of cellular senescence, a state of permanent cell cycle arrest that occurs in response to telomere shortening. **Pathways and Functions:** TERC is involved in several cellular pathways, including: 1. **Telomere Maintenance:** TERC is the template for the synthesis of telomeres, which are essential for maintaining chromosomal stability and preventing telomere shortening. 2. **Cellular Senescence:** TERC is involved in the regulation of cellular senescence, a state of permanent cell cycle arrest that occurs in response to telomere shortening. 3. **DNA Repair:** TERC is involved in the repair of DNA double-strand breaks through homologous recombination. 4. **Apoptosis:** TERC is involved in the regulation of apoptosis, a process of programmed cell death that occurs in response to cellular stress. **Clinical Significance:** Dysregulation of TERC has been implicated in various human diseases, including: 1. **Cancer:** Telomere shortening is a hallmark of cancer, and dysregulation of TERC has been associated with various types of cancer, including breast, lung, and colon cancer. 2. **Aging:** Telomere shortening is a key mechanism of aging, and dysregulation of TERC has been associated with age-related diseases, including cardiovascular disease and Alzheimer's disease. 3. **Neurodegenerative Diseases:** Telomere shortening has been implicated in neurodegenerative diseases, including Parkinson's disease and Huntington's disease. 4. **Immune System Disorders:** Dysregulation of TERC has been associated with immune system disorders, including autoimmune diseases and immunodeficiency syndromes. In conclusion, TERC is a crucial regulator of telomere length and cellular senescence. Its dysregulation has been implicated in various human diseases, including cancer, aging, neurodegenerative diseases, and immune system disorders. Further research is needed to fully understand the role of TERC in human disease and to develop therapeutic strategies to target this gene in the prevention and treatment of these diseases.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.