Details for: STOML1

Gene ID: 9399

Gene Type:  Protein-coding  - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: STOML1

Ensembl ID: ENSG00000067221

Description: stomatin like 1

Cell Significance Landscape

Associated with

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • progenitor cell CL0011026
    CSI 4.3
    rCSI 9.15%
    PRS 97.2
  • cerebral cortex neuron CL0010012
    CSI 2.55
    rCSI 10.37%
    PRS 96.28
  • peripheral nervous system neuron CL2000032
    CSI 2.07
    rCSI 2.83%
    PRS 97.83
  • L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040
    CSI 1.15
    rCSI 2.8%
    PRS 95.56

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

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Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [STOML1](/details-gene/9399), or Stomatin Like 1, is a protein-coding gene located on chromosome 15q24.1. It is a member of the stomatin/band 7 protein family, which is characterized by involvement in membrane-associated processes. Functional annotations indicate its localization to the [plasma membrane](/details-cell/GO:0005886), [membrane raft](/details-cell/GO:0045121), and [late endosome membrane](/details-cell/GO:0031902), where it participates in functions such as [protein binding](/details-cell/GO:0005515) and potentially [lipid transport](/details-cell/GO:0006869). Expression data highlights a significant role for [STOML1](/details-gene/9399) in the nervous system and in undifferentiated cell populations, with the highest significance observed in [progenitor cell](/details-cell/CL0011026) and various neuron subtypes, including [cerebral cortex neuron](/details-cell/CL0010012). ## Cellular Roles and Expression Landscape The expression profile of [STOML1](/details-gene/9399) suggests a specialized function within progenitor and neuronal cell lineages. * **Overall**, the gene exhibits its highest significance as a marker for [progenitor cell](/details-cell/CL0011026) (CSI: 4.30), indicating a potentially fundamental role in the biology of these undifferentiated cells. * Beyond progenitor populations, [STOML1](/details-gene/9399) is a significant marker in the nervous system. It is prominently expressed in [cerebral cortex neuron](/details-cell/CL0010012) (CSI: 2.55), [peripheral nervous system neuron](/details-cell/CL2000032) (CSI: 2.07), and more specifically in [L2/3-6 intratelencephalic projecting glutamatergic neuron](/details-cell/CL4023040) (CSI: 1.15). This pattern is consistent with early research identifying it as a brain-specific member of its protein family ([Link](https://doi.org/10.1016/s0378-1119(98)00532-0)). The collective data points to [STOML1](/details-gene/9399) as a key component of the molecular machinery in both developmental and mature neuronal contexts. ## Pathways and Molecular Function [STOML1](/details-gene/9399) is functionally annotated with roles related to membrane dynamics and protein-protein interactions. Its localization to [membrane raft](/details-cell/GO:0045121) microdomains suggests it may function as a scaffold or regulator within specialized signaling platforms on the cell surface. This is complemented by its annotated role in [lipid transport](/details-cell/GO:0006869), a common function for stomatin family members. The gene's capacity for [protein binding](/details-cell/GO:0005515) is supported by specific experimental evidence. Studies have demonstrated that STOML1 interacts with stomatin and is subsequently targeted to late endosomes, implying a role in endosomal trafficking pathways ([Link](https://doi.org/10.1074/jbc.m109.014993)). Furthermore, [STOML1](/details-gene/9399) has been shown to interact with components of the cell cycle and protein degradation machinery, specifically Cdk2 and the F-Box protein Fbw7-gamma ([Link](https://doi.org/10.1371/journal.pone.0047736)). This connection suggests that [STOML1](/details-gene/9399) may link membrane-associated events to the regulation of cell proliferation and protein turnover. ## Research Directions The specific expression pattern and known molecular interactions of [STOML1](/details-gene/9399) suggest several avenues for future investigation. Its high significance in both progenitor cells and mature neurons points to a dual role in development and maintenance of the nervous system. ### Testable Hypotheses 1. Given its high significance in [progenitor cell](/details-cell/CL0011026) and its interaction with the cell cycle regulator Cdk2 ([Link](https://doi.org/10.1371/journal.pone.0047736)), it is hypothesized that [STOML1](/details-gene/9399) functions as a key regulator of the balance between self-renewal and differentiation in progenitor populations, possibly by modulating signaling pathways within membrane rafts. 2. Based on its expression in multiple neuron types and its association with the F-box protein Fbw7-gamma, a component of ubiquitin ligase complexes, [STOML1](/details-gene/9399) may mediate the targeted degradation of specific substrates at the plasma membrane or in endosomes, thereby regulating neuronal signaling, synaptic plasticity, or axon maintenance. ### Proposed Experiment To test the hypothesis that [STOML1](/details-gene/9399) regulates progenitor cell fate, a CRISPR-Cas9 knockout could be generated in a human neural progenitor cell (NPC) line. The proliferation rate of [STOML1](/details-gene/9399)-knockout NPCs would be compared to isogenic wild-type controls using EdU incorporation assays. Subsequently, both cell populations would be subjected to differentiation protocols, and the efficiency of their conversion into neurons and glia would be quantified via immunofluorescence staining for lineage-specific markers (e.g., DCX for neuroblasts, MAP2 for mature neurons, and GFAP for astrocytes). Changes in the ability to self-renew versus differentiate would elucidate the functional role of [STOML1](/details-gene/9399) in this critical cell population. ### Therapeutic Potential The therapeutic potential of [STOML1](/details-gene/9399) is currently speculative. Its high expression in the central nervous system suggests that systemic targeting could lead to significant neurological side effects. However, its role in progenitor cells and its link to cell cycle regulation could make it a context-dependent target in diseases characterized by aberrant proliferation of progenitor-like cells, such as certain brain tumors (e.g., glioblastoma). In such a scenario, therapeutic inhibition of [STOML1](/details-gene/9399) function could potentially be explored as a strategy to suppress tumor growth or promote differentiation.

Genular Protein ID: 3764283728

Symbol: STML1_HUMAN

Name: Stomatin-like protein 1

UniProtKB Accession Codes:

Q9UBI4 B3KQN0 B4DUU5 B4DXM9 E7ESC0 H3BRP3 O95675 Q4PNR4 Q6FGL8 Q8WYI7 Q9UMB9 Q9UMC0 Q9Y6H9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 5 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 23 Ensembl 5 ExpressionAtlas 1 GO 4 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 5 RNAct 1 RefSeq 8 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 2 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9931417

Title: Molecular cloning of hSLP-1, a novel human brain-specific member of the band 7/MEC-2 family similar to Caenorhabditis elegans UNC-24.

PubMed ID: 9931417

DOI: 10.1016/s0378-1119(98)00532-0

PubMed ID: 10997330

Title: A novel gene STORP (STOmatin-Related Protein) is localized 2 kb upstream of the promyelocytic gene on chromosome 15q22.

PubMed ID: 10997330

DOI: 10.1034/j.1600-0609.2000.90054.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

PubMed ID: 16303743

Title: Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.

PubMed ID: 16303743

DOI: 10.1093/dnares/12.2.117

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19696025

Title: Stomatin-like protein-1 interacts with stomatin and is targeted to late endosomes.

PubMed ID: 19696025

DOI: 10.1074/jbc.m109.014993

PubMed ID: 23082202

Title: The stomatin-like protein SLP-1 and Cdk2 interact with the F-Box protein Fbw7-gamma.

PubMed ID: 23082202

DOI: 10.1371/journal.pone.0047736

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

Sequence Information:

  • Length: 398
  • Mass: 42968
  • Checksum: A9850C26394E1C3D
  • Sequence:
    • MLGRSGYRAL PLGDFDRFQQ SSFGFLGSQK GCLSPERGGV GTGADVPQSW PSCLCHGLIS 
FLGFLLLLVT FPISGWFALK IVPTYERMIV FRLGRIRTPQ GPGMVLLLPF IDSFQRVDLR 
TRAFNVPPCK LASKDGAVLS VGADVQFRIW DPVLSVMTVK DLNTATRMTA QNAMTKALLK 
RPLREIQMEK LKISDQLLLE INDVTRAWGL EVDRVELAVE AVLQPPQDSP AGPNLDSTLQ 
QLALHFLGGS MNSMAGGAPS PGPADTVEMV SEVEPPAPQV GARSSPKQPL AEGLLTALQP 
FLSEALVSQV GACYQFNVVL PSGTQSAYFL DLTTGRGRVG HGVPDGIPDV VVEMAEADLR 
ALLCRELRPL GAYMSGRLKV KGDLAMAMKL EAVLRALK

Genular Protein ID: 4264439641

Symbol: H3BST3_HUMAN

Name: N/A

UniProtKB Accession Codes:

H3BST3

Database IDs:

ARBA 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 1 Gene3D 2 GeneTree 1 HGNC 1 InterPro 6 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PeptideAtlas 2 Pfam 2 Proteomes 2 ProteomicsDB 2 RefSeq 1 SAM 1 SMART 2 SMR 1 SUPFAM 2 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

Sequence Information:

  • Length: 310
  • Mass: 33458
  • Checksum: BB4D402F90F5FA67
  • Sequence:
    • MIVFRLGRIR TPQGPGMVLL LPFIDSFQRV DLRTRAFNVP PCKLASKDGA VLSVGADVQF 
RIWDPVLSVM TVKDLNTATR MTAQNAMTKA LLKRPLREIQ MEKLKISDQL LLEINDVTRA 
WGLEVDRVEL AVEAVLQPPQ DSPAGPNLDS TLQQLALHFL GGSMNSMAGG APSPGPDTVE 
MVSEVEPPAP QVGARSSPKQ PLAEGLLTAL QPFLSEALVS QVGACYQFNV VLPSGTQSAY 
FLDLTTGRGR VGHGVPDGIP DVVVEMAEAD LRALLCRELR PLGAYMSGRL KVKGDLAMAM 
KLEAVLRALK

Genular Protein ID: 1268549728

Symbol: Q53HB6_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q53HB6

Database IDs:

ARBA 1 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 1 Gene3D 2 InterPro 6 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PeptideAtlas 1 Pfam 2 RefSeq 1 SAM 2 SMART 2 SUPFAM 2

Citations:

PubMed ID: 8125298

Title: Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.

PubMed ID: 8125298

DOI: 10.1016/0378-1119(94)90802-8

PubMed ID: 9373149

Title: Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.

PubMed ID: 9373149

DOI: 10.1016/S0378-1119(97)00411-3

Sequence Information:

  • Length: 397
  • Mass: 42881
  • Checksum: 4515AD83E3FBA658
  • Sequence:
    • MLGRSGYRAL PLGDFDRFQQ SSFGFLGSQK GCLSPERGGV GTGADVPQSW PSCLCHGLIS 
FPGFLLLLVT FPISGWFALK IVPTYERMIV FRLGRIRTPQ GPGMVLLLPF IDSFQRVDLR 
TRAFNVPPCK LASKDGAVLS VGADVQFRIW DPVLSVMTVK DLNTATRMTA QNAMTKALLK 
RPLREIQMEK LKISDQLLLE INDVTRAWGL EVDRVELAVE AVLQPPQDSP AGPNLDSTLQ 
QLALHFLGGS MNSMAGGAPS PGPDTVEMVS EVEPPAPQVG ARSSPKQPLA EGLLTALQPF 
LSEALVSQVG ACYQFNVVLP SGTQSAYFLD LTTGRGRVGH GVPDGIPDVV VEMAEADLRA 
LLCRELRPLG AYMSGRLKVK GDLAMAMKLE AVLRALK