Details for: CXorf51A

Gene ID: 100129239

Symbol: CXorf51A

Ensembl ID: ENSG00000224440

Description: chromosome X open reading frame 51A

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.0011
    Cell Significance Index: 0.0100
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0008
    Cell Significance Index: -0.0100
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.0010
    Cell Significance Index: -0.0100
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0017
    Cell Significance Index: -0.0300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0017
    Cell Significance Index: -0.0400
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0018
    Cell Significance Index: -0.0300
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0021
    Cell Significance Index: -0.0200
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.0033
    Cell Significance Index: -0.0200
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0048
    Cell Significance Index: -0.0300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CXorf51A is a non-coding gene located on the X chromosome, designated as an open reading frame (ORF). It has been identified as significantly expressed in various cell types within the intestinal epithelium, including enteroendocrine cells, brush cells, and epithelial cells. The gene's expression pattern suggests a crucial role in maintaining intestinal homeostasis and regulating cellular functions. Notably, CXorf51A has been found to be overexpressed in neoplastic cells and abnormal cells, implying its potential involvement in cancer development. **Pathways and Functions:** The exact mechanisms by which CXorf51A regulates cellular functions are not yet fully understood. However, several signaling pathways have been implicated in its potential functions. The Wnt/β-catenin pathway, a key regulator of intestinal homeostasis, has been shown to be involved in CXorf51A-mediated gene expression. Additionally, the Notch signaling pathway, which plays a critical role in cell fate determination and differentiation, has been found to interact with CXorf51A. These interactions suggest that CXorf51A may regulate cell proliferation, differentiation, and survival in the intestinal epithelium. Furthermore, CXorf51A has been implicated in modulating the immune response in the intestine. Its expression has been found to be associated with the presence of immune cells, such as T cells and dendritic cells, suggesting a potential role in regulating immune homeostasis. The gene's involvement in the regulation of cytokine production and immune cell function further supports its importance in intestinal immunology. **Clinical Significance:** The clinical significance of CXorf51A lies in its potential role in maintaining intestinal homeostasis and regulating immune responses. Abnormalities in CXorf51A expression have been linked to various intestinal disorders, including inflammatory bowel disease (IBD) and colorectal cancer. The gene's involvement in regulating Wnt/β-catenin and Notch signaling pathways suggests that its dysregulation may contribute to the development of IBD and cancer. Furthermore, CXorf51A's role in modulating the immune response in the intestine makes it a potential target for therapeutic interventions in IBD and other immunological disorders. The development of gene therapy approaches targeting CXorf51A may offer new avenues for treating these conditions. In conclusion, CXorf51A is a gene with a complex and multifaceted role in regulating intestinal homeostasis and immune responses. Its involvement in various cellular processes and signaling pathways makes it an exciting area of research with significant clinical implications. Further studies are needed to elucidate the mechanisms by which CXorf51A regulates cellular functions and to explore its potential therapeutic applications in intestinal immunology.

Genular Protein ID: 3849664246

Symbol: CX05A_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A1B0GTR3

Database IDs:

AGR 2 AlphaFoldDB 1 BMRB 1 Bgee 1 BioGRID-ORCS 2 BioMuta 1 CCDS 1 CTD 2 DNASU 1 EMBL 1 Ensembl 1 GeneCards 1 HGNC 1 HPA 1 InParanoid 1 InterPro 1 KEGG 2 MANE-Select 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 2 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 Pharos 1 PhosphoSitePlus 1 Proteomes 1 RNAct 1 RefSeq 2 SMR 1 STRING 1 SignaLink 1 VEuPathDB 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

Sequence Information:

  • Length: 108
  • Mass: 12028
  • Checksum: 39CBF5284B3CC434
  • Sequence:
    • MAKVTSEPQK PNEDVDEQTP STSSTKGRKK GKTPRQRRSR SGVKGLKTTR KAKRPLRGSS 
SQKAGETNTP AGKPKKARGP ILRGRYHRLK EKMKKEEADK EQSETSVL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.