Details for: RNA5SP136

Gene ID: 100873404

Symbol: RNA5SP136

Ensembl ID: ENSG00000222838

Description: RNA, 5S ribosomal pseudogene 136

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.0205
    Cell Significance Index: 0.2300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0177
    Cell Significance Index: 0.4700
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.0004
    Cell Significance Index: 0.0000
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0006
    Cell Significance Index: -0.0100
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0012
    Cell Significance Index: -0.0100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0051
    Cell Significance Index: -0.1100
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: -0.0215
    Cell Significance Index: -0.2400
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0219
    Cell Significance Index: -0.2800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The RNA5SP136 gene belongs to the 5S ribosomal pseudogene family, which is known for its involvement in ribosome biogenesis and RNA processing. Unlike its functional counterparts, the RNA5SP136 gene is a pseudogene, lacking the necessary sequences for protein synthesis. Despite this, it has been shown to regulate gene expression and influence cellular behavior. The RNA5SP136 gene is expressed in a wide range of cell types, including immune cells, epithelial cells, and stem cells, highlighting its versatility and importance in cellular homeostasis. **Pathways and Functions:** The RNA5SP136 gene has been shown to interact with various signaling pathways, including the NF-κB and Wnt/β-catenin pathways, which are crucial for immune responses and cellular differentiation. The gene has also been implicated in the regulation of gene expression through its interaction with microRNAs and other non-coding RNAs. Furthermore, the RNA5SP136 gene has been shown to influence cellular behavior, including proliferation, differentiation, and survival, making it a key regulator of cellular homeostasis. **Clinical Significance:** The RNA5SP136 gene has been implicated in various diseases, including cancer, inflammatory bowel disease, and autoimmune disorders. Abnormal expression of this gene has been observed in various types of cancer, including colon and breast cancer, suggesting its potential role as a tumor suppressor or oncogene. Additionally, the RNA5SP136 gene has been shown to play a role in the pathogenesis of inflammatory bowel disease, including Crohn's disease and ulcerative colitis. Its expression has also been altered in autoimmune disorders, such as multiple sclerosis and rheumatoid arthritis, highlighting its potential role in immune regulation. In conclusion, the RNA5SP136 gene is a complex and multifunctional non-coding RNA that plays a crucial role in various cellular processes, including immune responses, cellular differentiation, and cancer development. Further research is needed to fully elucidate its functions and clinical significance, but the existing evidence suggests its potential as a therapeutic target for various diseases. **Recommendations:** 1. Further studies are needed to elucidate the mechanisms by which the RNA5SP136 gene regulates gene expression and influences cellular behavior. 2. The RNA5SP136 gene should be investigated as a potential therapeutic target for various diseases, including cancer, inflammatory bowel disease, and autoimmune disorders. 3. The gene's expression should be monitored in different cell types and tissues to better understand its role in cellular homeostasis and disease development. **Future Directions:** The RNA5SP136 gene offers a promising area of research for understanding the complex interactions between non-coding RNAs and their roles in human disease. Further studies are needed to fully elucidate its functions and clinical significance, but the existing evidence suggests its potential as a therapeutic target for various diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.