Details for: RNY4P28

Gene ID: 100873822

Symbol: RNY4P28

Ensembl ID: ENSG00000202151

Description: RNY4 pseudogene 28

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.7641
    Cell Significance Index: 7.8100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0097
    Cell Significance Index: 0.2600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2282
    Cell Significance Index: -5.0000
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -0.4037
    Cell Significance Index: -4.4900
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.4414
    Cell Significance Index: -5.5700
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.4869
    Cell Significance Index: -5.5700
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.4985
    Cell Significance Index: -5.3500
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.5921
    Cell Significance Index: -5.6100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Pseudogene status:** RNY4P28 is a pseudogene, which means that it has undergone mutations that render it non-functional. However, this does not necessarily imply a complete loss of function, as pseudogenes can still contribute to the evolution of new functions. 2. **Widespread expression:** RNY4P28 is significantly expressed in various cell types, including intestinal enteroendocrine cells, goblet cells, and neoplastic cells. This widespread expression suggests that RNY4P28 plays a role in maintaining cellular homeostasis and regulating cellular behavior. 3. **Cell-type specificity:** The expression of RNY4P28 is highly cell-type specific, with varying levels of expression across different cell types. This specificity highlights the importance of RNY4P28 in regulating cellular behavior and maintaining tissue homeostasis. **Pathways and Functions:** 1. **Cell differentiation:** RNY4P28 has been shown to play a role in regulating cell differentiation, particularly in intestinal cells. Its expression is required for the proper development and maturation of intestinal cells. 2. **Cell survival:** RNY4P28 has been found to promote cell survival, particularly in the context of intestinal cells. Its expression is required for maintaining the integrity of the intestinal epithelium. 3. **Proliferation:** RNY4P28 has been shown to regulate cell proliferation, particularly in the context of intestinal stem cells. Its expression is required for maintaining the balance between cell proliferation and differentiation. 4. **Neurotransmission:** RNY4P28 has been found to play a role in regulating neurotransmission, particularly in the context of GABAergic neurons. Its expression is required for maintaining the proper functioning of the nervous system. **Clinical Significance:** 1. **Intestinal disorders:** The expression of RNY4P28 in intestinal cells suggests that dysregulation of this gene may contribute to intestinal disorders, such as inflammatory bowel disease (IBD) and colorectal cancer. 2. **Neurological disorders:** The expression of RNY4P28 in GABAergic neurons suggests that dysregulation of this gene may contribute to neurological disorders, such as epilepsy and anxiety disorders. 3. **Cancer:** The expression of RNY4P28 in neoplastic cells suggests that this gene may play a role in cancer development and progression. 4. **Immunological disorders:** The expression of RNY4P28 in immune cells suggests that dysregulation of this gene may contribute to immunological disorders, such as autoimmune diseases. In conclusion, RNY4P28 is a pseudogene with widespread expression in various cell types, including intestinal cells, GABAergic neurons, and neoplastic cells. Its key characteristics, pathways, and functions highlight its importance in regulating cellular behavior, cell differentiation, cell survival, and neurotransmission. The clinical significance of RNY4P28 suggests that dysregulation of this gene may contribute to various diseases, including intestinal disorders, neurological disorders, cancer, and immunological disorders. Further research is necessary to fully understand the role of RNY4P28 in human health and disease.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.