Details for: LOC101928819

Gene ID: 101928819

Gene Type:  ncRNA (Non-coding RNA)  - A functional RNA molecule that is transcribed from DNA but not translated into a protein. Includes classes like miRNA and lncRNA.

Symbol: LOC101928819

Ensembl ID: ENSG00000250978

Description: uncharacterized LOC101928819

Cell Significance Landscape

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • pulmonary alveolar type 2 cell CL0002063
    CSI 2.92
    rCSI 4.53%
    PRS 98.28
  • pulmonary alveolar type 1 cell CL0002062
    CSI 2.89
    rCSI 16.65%
    PRS 97.23
  • retinal cone cell CL0000573
    CSI 2.84
    rCSI 4.57%
    PRS 95.3
  • S cone cell CL0003050
    CSI 1.46
    rCSI 6.42%
    PRS 96.22

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Comma-separated if multiple.
Comma-separated if multiple.
Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [LOC101928819](/details-gene/101928819) is an uncharacterized non-coding RNA (ncRNA) gene located on human chromosome 5. Current expression data indicates a highly specialized role, with significant and specific expression restricted to distinct cell types in the lung and the retina. Its high significance in both [pulmonary alveolar type 1](/details-cell/CL0002062) and [type 2 cells](/details-cell/CL0002063), as well as [retinal cone cells](/details-cell/CL0000573), suggests it may be involved in the unique biological functions of these terminally differentiated cells, such as gas exchange, surfactant production, or phototransduction. ## Cellular Roles and Expression Landscape **Overall**, the expression profile of [LOC101928819](/details-gene/101928819) points to a highly specific function in two separate organ systems. In the respiratory system, it is a prominent marker for the lung alveoli. It shows nearly equivalent high significance in both [pulmonary alveolar type 2 cell](/details-cell/CL0002063) (CSI: 2.92), which are responsible for surfactant production and acting as progenitors, and [pulmonary alveolar type 1 cell](/details-cell/CL0002062) (CSI: 2.89), which form the primary surface for gas exchange. This dual expression suggests a potential role in maintaining the structural or functional integrity of the entire alveolar unit. In the visual system, [LOC101928819](/details-gene/101928819) is also highly significant in [retinal cone cells](/details-cell/CL0000573) (CSI: 2.84), the photoreceptors responsible for color vision and high-acuity daytime vision. Its presence is also noted in the more specific [S cone cell](/details-cell/CL0003050) subtype (CSI: 1.46). This specific expression pattern is consistent with a potential role in cone cell development, function, or long-term survival. The limited expression data available highlights a highly specialized role for this ncRNA, rather than a ubiquitous housekeeping function. ## Pathways and Molecular Function As an uncharacterized ncRNA, the precise molecular function of [LOC101928819](/details-gene/101928819) remains unknown. It is not currently associated with any annotated pathways in databases such as Reactome or Gene Ontology. Based on its classification, it may function as a long non-coding RNA (lncRNA) to regulate gene expression within its target cells. Potential mechanisms include guiding epigenetic modifiers to specific genomic loci, acting as a molecular sponge to sequester microRNAs, or modulating the stability and translation of target mRNAs. Its function is likely tailored to the unique physiological demands of pulmonary alveolar cells and retinal cone cells. ## Research Directions The highly specific expression of [LOC101928819](/details-gene/101928819) in two critical and physiologically distinct cell types makes it a compelling subject for further investigation, particularly in the context of disease. A key direction would be to analyze its expression in pathological conditions such as acute respiratory distress syndrome (ARDS), idiopathic pulmonary fibrosis, or retinal degenerative diseases like macular degeneration. Based on the available data, several testable hypotheses can be proposed: 1. In the lung, [LOC101928819](/details-gene/101928819) may act as a critical regulator of alveolar cell homeostasis. Its downregulation could impair the ability of [pulmonary alveolar type 2 cells](/details-cell/CL0002063) to produce surfactant or differentiate into [pulmonary alveolar type 1 cells](/details-cell/CL0002062) during injury repair, thereby contributing to alveolar collapse and respiratory failure. 2. In the retina, [LOC101928819](/details-gene/101928819) could be essential for the survival and function of [retinal cone cells](/details-cell/CL0000573). Its loss may lead to increased cellular stress or apoptosis, contributing to the progression of diseases characterized by cone photoreceptor death. To test the hypothesis regarding its role in alveolar cell function, a key experiment could involve the use of antisense oligonucleotides (ASOs) to specifically knock down [LOC101928819](/details-gene/101928819) in a lung organoid model derived from human induced pluripotent stem cells. Following knockdown, single-cell RNA sequencing could be performed to identify downstream transcriptional changes and to assess the differentiation trajectory and functional state of alveolar epithelial cells, particularly the expression of key surfactant protein genes. Given its highly restricted expression profile, [LOC101928819](/details-gene/101928819) holds potential as a therapeutic target or biomarker. If its dysregulation contributes to lung or retinal disease, therapies targeting this ncRNA, such as ASO-mediated inhibition or RNA-based activation strategies, could offer high specificity with potentially minimal off-target effects. Its cell-type specificity also makes it a candidate biomarker for monitoring the health of alveolar or cone cell populations through liquid biopsies or other sensitive detection methods.