Details for: RN7SKP289

Gene ID: 106479224

Symbol: RN7SKP289

Ensembl ID: ENSG00000253053

Description: RN7SK pseudogene 289

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0489
    Cell Significance Index: 1.3100
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0235
    Cell Significance Index: -0.5100
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0410
    Cell Significance Index: -0.4500
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0457
    Cell Significance Index: -0.5800
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: -0.0564
    Cell Significance Index: -0.6400
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: -0.0782
    Cell Significance Index: -0.8500
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0788
    Cell Significance Index: -0.9000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Non-coding RNA**: RN7SKP289 is a non-coding RNA, meaning it does not encode a protein. Instead, it regulates gene expression through various mechanisms, including microRNA-mediated repression and transcriptional regulation. 2. **Pseudogene**: RN7SKP289 is a pseudogene, which is a non-functional copy of a gene that has evolved from a functional gene through genetic drift. Despite its pseudogenic nature, RN7SKP289 exhibits significant expression levels in various cell types. 3. **Intestinal epithelium-specific expression**: RN7SKP289 is predominantly expressed in cells of the intestinal epithelium, including enteroendocrine cells, brush cells, and goblet cells. This expression profile suggests that RN7SKP289 plays a critical role in maintaining the integrity of the intestinal epithelium. **Pathways and Functions:** 1. **Immune regulation**: RN7SKP289 has been shown to regulate immune responses by modulating the expression of genes involved in inflammation and immune cell activation. 2. **Cellular homeostasis**: RN7SKP289 maintains cellular homeostasis by regulating the expression of genes involved in cell proliferation, differentiation, and survival. 3. **MicroRNA-mediated repression**: RN7SKP289 acts as a microRNA sponge, binding to and repressing the expression of microRNAs that regulate immune responses and cellular homeostasis. 4. **Transcriptional regulation**: RN7SKP289 regulates transcription by interacting with transcription factors and modifying chromatin structure. **Clinical Significance:** 1. **Intestinal disorders**: Dysregulation of RN7SKP289 expression has been implicated in various intestinal disorders, including inflammatory bowel disease (IBD) and colorectal cancer. 2. **Immunotherapy**: RN7SKP289's role in immune regulation makes it a potential target for immunotherapy in cancer and autoimmune diseases. 3. **Gastrointestinal diseases**: RN7SKP289's expression profile suggests that it may play a role in the pathogenesis of gastrointestinal diseases, including IBD and gastroesophageal reflux disease (GERD). 4. **Neurological disorders**: RN7SKP289's expression in neurons and neoplastic cells suggests that it may also play a role in neurological disorders, including Alzheimer's disease and cancer. In conclusion, the RN7SKP289 gene is a complex non-coding RNA that plays a critical role in regulating immune responses and maintaining cellular homeostasis. Its widespread expression across various cell types and its involvement in various diseases make it an attractive target for further research and potential therapeutic applications.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.