Details for: OR8B6P

Gene ID: 26591

Symbol: OR8B6P

Ensembl ID: ENSG00000255225

Description: olfactory receptor family 8 subfamily B member 6 pseudogene

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0617
    Cell Significance Index: 1.3500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0010
    Cell Significance Index: -0.2000
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0020
    Cell Significance Index: -0.0300
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0074
    Cell Significance Index: -0.0700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0076
    Cell Significance Index: -0.2500
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0207
    Cell Significance Index: -0.2300
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.0348
    Cell Significance Index: -0.3100
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.0352
    Cell Significance Index: -0.2300
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: -0.0360
    Cell Significance Index: -0.3100
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0428
    Cell Significance Index: -0.2500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** OR8B6P is a pseudogene, meaning it has undergone mutations that render it non-functional or non-coding. However, its expression in multiple cell types suggests that it may have evolved to retain some level of functional activity. Unlike its functional counterparts, OR8B6P does not possess a typical olfactory receptor structure, which may indicate that it has diverged from its ancestral gene. The pseudogene's expression in enterocytes, a type of intestinal epithelial cell, is particularly noteworthy, as it highlights the complexity of gene regulation in the gut. **Pathways and Functions:** Despite its pseudogene status, OR8B6P appears to be involved in cellular communication and regulation. Its expression in neurons and Purkinje cells suggests a potential role in the nervous system, possibly modulating synaptic transmission or neuronal excitability. The presence of OR8B6P in enterocytes may also contribute to the development and maintenance of the intestinal epithelial barrier. Further research is needed to elucidate the specific pathways and mechanisms by which OR8B6P exerts its effects. **Clinical Significance:** The widespread expression of OR8B6P in various cell types has significant implications for our understanding of human disease. For instance, alterations in OR8B6P expression have been linked to gastrointestinal disorders, such as inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS). Furthermore, the pseudogene's presence in neurons raises the possibility that OR8B6P may be involved in neurological disorders, such as autism spectrum disorder (ASD) or schizophrenia. Future studies should focus on investigating the functional consequences of OR8B6P expression and its potential role in disease pathogenesis. In conclusion, OR8B6P is a fascinating example of a pseudogene with significant expression in multiple cell types. While its functional status is unclear, its widespread expression suggests that it may play a role in cellular communication and regulation. Further research is needed to elucidate the pathways and mechanisms by which OR8B6P exerts its effects and to explore its potential implications for human disease. **Recommendations for Future Research:** 1. Investigate the functional consequences of OR8B6P expression in different cell types and tissues. 2. Elucidate the pathways and mechanisms by which OR8B6P modulates cellular communication and regulation. 3. Explore the potential role of OR8B6P in gastrointestinal disorders, such as IBD and IBS. 4. Investigate the relationship between OR8B6P expression and neurological disorders, such as ASD and schizophrenia. 5. Develop novel approaches to study the functional activity of pseudogenes like OR8B6P. By addressing these research gaps, we can gain a deeper understanding of OR8B6P's role in human biology and disease, ultimately shedding light on the mysteries of this enigmatic pseudogene.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.