Details for: RNU1 2

Gene ID: 26870

Symbol: RNU1 2

Ensembl ID: ENSG00000207005

Description: RNA, U1 small nuclear 2

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.1182
    Cell Significance Index: 1.4900
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.1050
    Cell Significance Index: 1.1700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0030
    Cell Significance Index: 0.0800
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -0.0018
    Cell Significance Index: -0.0200
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0027
    Cell Significance Index: -0.0300
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0059
    Cell Significance Index: -0.1000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0117
    Cell Significance Index: -0.1400
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0133
    Cell Significance Index: -0.1600
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0149
    Cell Significance Index: -0.1400
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.0159
    Cell Significance Index: -0.1600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** RNU1 is a small nuclear RNA (snRNA) that belongs to the U1 snRNA family, which plays a crucial role in the splicing of pre-mRNA during RNA processing. The expression of RNU1 is widespread, with significant levels found in various cell types, including immune cells. This suggests that RNU1 may be involved in the regulation of immune responses and cellular homeostasis. Notably, RNU1 has been shown to interact with other RNAs, such as microRNAs and long non-coding RNAs, to modulate gene expression and regulate cellular processes. **Pathways and Functions:** The mechanisms underlying the functions of RNU1 are complex and multifaceted. Research has implicated RNU1 in various cellular processes, including: 1. **RNA processing:** RNU1 participates in the splicing of pre-mRNA, regulating the expression of genes involved in immune responses and cellular homeostasis. 2. **Gene regulation:** RNU1 interacts with other RNAs to modulate gene expression, influencing the transcription of genes involved in immune responses, cell proliferation, and differentiation. 3. **Immune regulation:** RNU1 has been shown to modulate immune responses by regulating the expression of genes involved in immune cell function, such as cytokine production and cell surface receptor expression. 4. **Cellular homeostasis:** RNU1 may play a role in maintaining cellular homeostasis by regulating the expression of genes involved in cell proliferation, differentiation, and survival. **Clinical Significance:** The clinical significance of RNU1 is an area of active research. Dysregulation of RNU1 has been implicated in various immune-related disorders, including: 1. **Autoimmune diseases:** RNU1 may play a role in the pathogenesis of autoimmune diseases, such as rheumatoid arthritis and lupus, by regulating immune responses and promoting inflammation. 2. **Cancer:** RNU1 has been shown to be overexpressed in certain types of cancer, including lymphoma and leukemia, suggesting a potential role in tumorigenesis. 3. **Inflammatory bowel disease:** RNU1 may contribute to the pathogenesis of inflammatory bowel disease by regulating the expression of genes involved in inflammation and immune responses. In conclusion, RNU1 is a multifunctional gene that plays a critical role in immune regulation and cellular homeostasis. Further research is needed to fully elucidate the mechanisms underlying the functions of RNU1 and its clinical significance in immune-related disorders.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.