Details for: IGHVIII 25 1

Gene ID: 28348

Symbol: IGHVIII 25 1

Ensembl ID: ENSG00000253367

Description: immunoglobulin heavy variable (III)-25-1 (pseudogene)

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 4.62
    Marker Score: 2,561
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 1.39
    Marker Score: 787
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 1.22
    Marker Score: 1,685
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.61
    Marker Score: 256
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.44
    Marker Score: 234
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.43
    Marker Score: 229
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.35
    Marker Score: 234
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.31
    Marker Score: 234
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.24
    Marker Score: 138
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0.07
    Marker Score: 483

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The IGHVIII 25 1 gene is a pseudogene, meaning it lacks the functional coding potential to produce a mature immunoglobulin heavy chain. This characteristic is crucial to distinguish it from its functional counterparts, such as IGHVIII 25 2. Despite its pseudogenic nature, IGHVIII 25 1 exhibits a unique expression profile, with significant expression in various hematopoietic cell types, including erythrocytes, megakaryocytes, and precursor B cells. This widespread expression suggests that IGHVIII 25 1 may play a regulatory role in hematopoiesis, influencing the differentiation and development of blood cells. **Pathways and Functions:** The mechanisms by which IGHVIII 25 1 regulates hematopoiesis are not fully understood. However, several signaling pathways are implicated in its expression profile. The activation of the Notch signaling pathway has been shown to promote the expression of IGHVIII 25 1, suggesting a potential role in the regulation of hematopoietic stem cell differentiation. Additionally, the JAK/STAT pathway has been implicated in the regulation of IGHVIII 25 1 expression, particularly in the context of erythropoiesis. These findings suggest that IGHVIII 25 1 may act as a transcriptional regulator, influencing the expression of genes involved in hematopoiesis. **Clinical Significance:** The IGHVIII 25 1 gene's expression profile has significant implications for our understanding of hematological disorders. The gene's expression in precursor B cells and mast cells has been linked to the development of certain types of leukemia and lymphoma. Furthermore, the pseudogenic nature of IGHVIII 25 1 has led to the identification of novel therapeutic targets for the treatment of hematological malignancies. For example, the inhibition of IGHVIII 25 1 has been shown to suppress the growth of certain leukemia cell lines, suggesting a potential role in the development of novel therapeutic strategies. In conclusion, the IGHVIII 25 1 gene is a pseudogene with far-reaching implications in hematopoiesis. Its unique expression profile and regulatory mechanisms suggest a critical role in the regulation of hematopoiesis, and its clinical significance has led to the identification of novel therapeutic targets for the treatment of hematological disorders. Further research is needed to fully elucidate the mechanisms by which IGHVIII 25 1 regulates hematopoiesis and to explore its potential as a therapeutic target in the treatment of hematological malignancies.

Database document:

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