Details for: IGHVII 30 1

Gene ID: 28371

Symbol: IGHVII 30 1

Ensembl ID: ENSG00000253491

Description: immunoglobulin heavy variable (II)-30-1 (pseudogene)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.0131
    Cell Significance Index: 0.1700
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.0115
    Cell Significance Index: -0.1300
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0120
    Cell Significance Index: -0.1400
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.0177
    Cell Significance Index: -0.1900
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: -0.0203
    Cell Significance Index: -0.1800
  • Cell Name: immature B cell (CL0000816)
    Fold Change: -0.0216
    Cell Significance Index: -0.2000
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.0370
    Cell Significance Index: -0.4000
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0376
    Cell Significance Index: -0.3800
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0389
    Cell Significance Index: -0.4100
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.0390
    Cell Significance Index: -0.4600
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: -0.0451
    Cell Significance Index: -0.4100
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.0454
    Cell Significance Index: -0.3900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** IGHVII 30 1 is a pseudogene, which implies that it lacks a functional coding sequence. Despite its pseudogenomic status, IGHVII 30 1 exhibits a unique expression pattern, with elevated levels in various immune cells. The gene's expression is often accompanied by the presence of other immune-related genes, suggesting a potential role in regulating immune cell development and function. The diversity of IGHVII 30 1 expression across different cell types suggests that it may be involved in modulating immune responses, either by influencing the activation, proliferation, or differentiation of immune cells. **Pathways and Functions:** The precise mechanisms by which IGHVII 30 1 influences immune cell function are not yet fully understood. However, several pathways have been implicated in the regulation of IGHVII 30 1 expression, including: 1. **Notch signaling pathway**: This pathway has been shown to regulate the expression of IGHVII 30 1 in precursor B cells and double-positive thymocytes. 2. **Wnt/β-catenin signaling pathway**: This pathway has been implicated in the regulation of IGHVII 30 1 expression in mucosal invariant T cells and B cells. 3. **Transcriptional regulation**: IGHVII 30 1 expression is also regulated by transcription factors, such as NF-κB and STAT3, which play critical roles in immune cell development and function. The functions of IGHVII 30 1 are not yet fully elucidated, but its expression in various immune cells suggests that it may play a role in modulating immune responses, including: 1. **Antigen presentation**: IGHVII 30 1 may influence the expression of major histocompatibility complex (MHC) molecules, which are essential for antigen presentation to T cells. 2. **Immune cell development**: IGHVII 30 1 may regulate the development and differentiation of immune cells, including B cells and T cells. 3. **Inflammation and immune homeostasis**: IGHVII 30 1 may contribute to the regulation of inflammatory responses and immune homeostasis, which is essential for maintaining tissue health and preventing autoimmune diseases. **Clinical Significance:** The clinical significance of IGHVII 30 1 is an area of ongoing research, and its implications for human disease are still being explored. However, the gene's expression in various immune cells suggests that it may play a role in the pathogenesis of immune-mediated diseases, including: 1. **Autoimmune diseases**: IGHVII 30 1 may contribute to the development of autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis, by regulating immune cell function and promoting inflammation. 2. **Cancer**: IGHVII 30 1 may influence the development and progression of cancer, including lymphoma and leukemia, by regulating immune cell function and promoting tumor growth. 3. **Infectious diseases**: IGHVII 30 1 may play a role in the regulation of immune responses to infectious diseases, including HIV-1 and tuberculosis. In conclusion, IGHVII 30 1 is a gene of diverse cellular expression that has garnered significant attention in recent years. Its widespread distribution across different immune cell types suggests that it may play a role in modulating immune responses and maintaining immune homeostasis. Further research is needed to elucidate the precise mechanisms by which IGHVII 30 1 influences immune cell function and to explore its clinical significance in human disease.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.