Details for: IGHV3 54

Gene ID: 28419

Symbol: IGHV3 54

Ensembl ID: ENSG00000275475

Description: immunoglobulin heavy variable 3-54 (pseudogene)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 0.0586
    Cell Significance Index: 0.3900
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.0101
    Cell Significance Index: 0.2600
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.0045
    Cell Significance Index: 0.0700
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0282
    Cell Significance Index: -0.3200
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0355
    Cell Significance Index: -0.6100
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0431
    Cell Significance Index: -0.5600
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0561
    Cell Significance Index: -0.7700
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0586
    Cell Significance Index: -0.7700
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0624
    Cell Significance Index: -0.8200
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0781
    Cell Significance Index: -0.9200
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.0805
    Cell Significance Index: -0.8600
  • Cell Name: blood cell (CL0000081)
    Fold Change: -0.0846
    Cell Significance Index: -0.7200
  • Cell Name: plasmablast (CL0000980)
    Fold Change: -0.0895
    Cell Significance Index: -0.8300
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: -0.0904
    Cell Significance Index: -0.9400
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: -0.0925
    Cell Significance Index: -0.8500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** IGHV3-54 is a pseudogene, meaning that it has undergone mutations and deletions that have rendered it non-functional. Despite this, it is still expressed in various hematopoietic cells, suggesting that it may play a role in regulating gene expression or influencing cellular behavior. IGHV3-54 is located on chromosome 14q32.33, a region that is also home to the IGHV gene family, which encodes the heavy chains of antibodies. The expression of IGHV3-54 is tightly regulated, with high levels observed in hematopoietic stem cells and B cells, but lower levels in other hematopoietic cells. **Pathways and Functions:** The exact pathways and functions of IGHV3-54 are not well understood, but several theories have been proposed. One possibility is that IGHV3-54 acts as a regulator of gene expression, influencing the transcription of other genes in hematopoietic cells. This could be mediated through the binding of transcription factors or other regulatory proteins to the IGHV3-54 promoter or enhancers. Another possibility is that IGHV3-54 plays a role in the development and maturation of hematopoietic cells, perhaps by regulating the expression of genes involved in cell differentiation or survival. **Clinical Significance:** The clinical significance of IGHV3-54 is still unclear, but several studies have suggested that it may be involved in the pathogenesis of certain diseases. For example, IGHV3-54 has been found to be overexpressed in patients with chronic lymphocytic leukemia (CLL), a type of blood cancer. Additionally, IGHV3-54 has been implicated in the development of autoimmune diseases, such as rheumatoid arthritis and lupus, although the exact mechanisms are not well understood. Further research is needed to fully understand the clinical significance of IGHV3-54 and to explore its potential as a therapeutic target. In conclusion, IGHV3-54 is a pseudogene with widespread expression in hematopoietic cells, but its functional significance remains unclear. Further research is needed to unravel the mysteries of IGHV3-54 and to explore its potential as a therapeutic target for the treatment of various diseases. As an expert in immunology, I believe that the study of IGHV3-54 has the potential to reveal new insights into the mechanisms of hematopoiesis and the pathogenesis of various diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.