Details for: IGHV3 30 2

Gene ID: 28438

Symbol: IGHV3 30 2

Ensembl ID: ENSG00000253587

Description: immunoglobulin heavy variable 3-30-2 (pseudogene)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.0023
    Cell Significance Index: 0.0300
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 0.0019
    Cell Significance Index: 0.0200
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 0.0006
    Cell Significance Index: 0.0100
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.0042
    Cell Significance Index: -0.0400
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.0052
    Cell Significance Index: -0.0600
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0271
    Cell Significance Index: -0.2700
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0303
    Cell Significance Index: -0.3800
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.0305
    Cell Significance Index: -0.3600
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0348
    Cell Significance Index: -0.4100
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.0353
    Cell Significance Index: -0.3800
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0804
    Cell Significance Index: -0.7500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** IGHV3-30-2 is a pseudogene, meaning that it is a non-functional copy of the immunoglobulin heavy chain gene that has undergone mutations and deletions, rendering it unable to produce a functional protein. Despite its non-functional status, IGHV3-30-2 is highly expressed in various immune cells, including those that are essential for adaptive immune responses. This expression suggests that IGHV3-30-2 may play a regulatory role in the development and function of these cells. **Pathways and Functions:** The expression of IGHV3-30-2 in immune cells suggests that it is involved in the regulation of gene expression, particularly in the context of immune cell development. One possible function of IGHV3-30-2 is to act as a decoy or a competitor for functional immunoglobulin heavy chain genes, thereby modulating the expression of these genes. This could have significant implications for the development and function of immune cells, as it may influence the selection of B cells and T cells that express functional immunoglobulins. Another possible function of IGHV3-30-2 is to regulate the expression of genes involved in the development and function of immune cells. For example, IGHV3-30-2 may interact with other regulatory elements, such as enhancers or silencers, to influence the expression of genes involved in immune cell development and function. **Clinical Significance:** The expression of IGHV3-30-2 in immune cells has significant implications for our understanding of immune cell development and function. The fact that this pseudogene is highly expressed in cells that are essential for adaptive immune responses suggests that it may play a regulatory role in the development and function of these cells. Furthermore, the expression of IGHV3-30-2 in B cells and memory B cells may have implications for the development of autoimmune diseases, such as autoimmune hemolytic anemia, where B cells produce autoantibodies against self-antigens. The presence of IGHV3-30-2 in these cells may influence the selection of B cells that produce autoantibodies, thereby contributing to the development of autoimmune diseases. In conclusion, the immunoglobulin heavy variable 3-30-2 gene is a pseudogene that plays a significant role in the development and function of various immune cells. Its expression in cells that are essential for adaptive immune responses highlights the complexity of immune cell development and the importance of pseudogenes in regulating gene expression. Further studies are needed to fully understand the functions of IGHV3-30-2 and its implications for human disease.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.