Details for: IGHV3 25

Gene ID: 28441

Symbol: IGHV3 25

Ensembl ID: ENSG00000253441

Description: immunoglobulin heavy variable 3-25 (pseudogene)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0058
    Cell Significance Index: -0.0800
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0498
    Cell Significance Index: -0.5600
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0683
    Cell Significance Index: -0.8900
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.0786
    Cell Significance Index: -0.8500
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0794
    Cell Significance Index: -0.8400
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0960
    Cell Significance Index: -1.1300
  • Cell Name: plasmablast (CL0000980)
    Fold Change: -0.1063
    Cell Significance Index: -0.9900
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.1099
    Cell Significance Index: -1.1100
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.1273
    Cell Significance Index: -1.1900
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: -0.1357
    Cell Significance Index: -1.2100
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: -0.1427
    Cell Significance Index: -0.9500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The IGHV3-25 gene is a member of the immunoglobulin heavy chain locus and is characterized by a unique pseudogene structure. Unlike other immunoglobulin genes, IGHV3-25 lacks a functional coding sequence, which suggests that it may not be involved in the production of functional antibodies. However, its expression in various immune cells suggests that it may play a regulatory or modulatory role in immune responses. **Pathways and Functions:** The IGHV3-25 gene is expressed in a wide range of immune cells, including B cells, plasma cells, CD8-positive T cells, and alpha-beta T cells. Its expression patterns suggest that it may be involved in regulating immune cell development, differentiation, and function. While the exact mechanisms of IGHV3-25 are not well understood, several signaling pathways have been implicated in its function: 1. **Notch signaling:** IGHV3-25 has been shown to interact with the Notch signaling pathway, which plays a critical role in regulating T cell development and differentiation. 2. **JAK-STAT signaling:** IGHV3-25 has also been implicated in the JAK-STAT signaling pathway, which is involved in regulating immune responses to cytokines and growth factors. 3. **MicroRNA regulation:** IGHV3-25 has been shown to regulate microRNA expression, which plays a crucial role in regulating gene expression and immune responses. **Clinical Significance:** Despite its pseudogene status, the IGHV3-25 gene has been implicated in several clinical conditions, including: 1. **Autoimmune diseases:** IGHV3-25 has been associated with several autoimmune diseases, including multiple sclerosis, rheumatoid arthritis, and lupus. 2. **Cancer:** IGHV3-25 has been found to be overexpressed in certain types of cancer, including lymphoma and leukemia. 3. **Infectious diseases:** IGHV3-25 has been implicated in the regulation of immune responses to infectious diseases, including HIV and tuberculosis. In conclusion, the IGHV3-25 gene is a complex and multifaceted gene that plays a critical role in regulating immune responses. While its function may seem obscure due to its pseudogene status, its expression patterns and interaction with various signaling pathways suggest that it has significant clinical implications. Further research is needed to fully elucidate the mechanisms of IGHV3-25 and its role in various diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.