Details for: HPRT1P3

Gene ID: 3255

Symbol: HPRT1P3

Ensembl ID: ENSG00000256752

Description: hypoxanthine phosphoribosyltransferase 1 pseudogene 3

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 0.0060
    Cell Significance Index: 0.0500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0007
    Cell Significance Index: -0.0100
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0019
    Cell Significance Index: -0.0400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0019
    Cell Significance Index: -0.0400
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0022
    Cell Significance Index: -0.0300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0027
    Cell Significance Index: -0.0300
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.0048
    Cell Significance Index: -0.0500
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.0066
    Cell Significance Index: -0.0800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** HPRT1P3 is a pseudogene, meaning it lacks a functional coding sequence that can produce a protein. Despite its pseudogenic nature, HPRT1P3 exhibits significant expression in a range of cell types, including stromal cells, which are known for their role in tissue repair and regeneration. Notably, HPRT1P3 is also expressed in neurons and retinal rod cells, suggesting its involvement in neural function and photoreception. Interestingly, HPRT1P3 shows a high degree of similarity to its functional homolog, HPRT1, which is involved in the salvage pathway of purine metabolism. This similarity raises the possibility that HPRT1P3 may serve as a regulatory or compensatory mechanism to modulate HPRT1 activity. **Pathways and Functions:** The HPRT1P3 gene is likely involved in the regulation of purine metabolism, particularly in the context of cellular stress and oxidative damage. As a pseudogene, HPRT1P3 may influence the activity of its functional homolog, HPRT1, by modulating the expression of genes involved in the salvage pathway. One potential function of HPRT1P3 is to act as a molecular chaperone, protecting HPRT1 from oxidative damage and promoting its activity in response to stress. This could be particularly relevant in neurons, where oxidative stress is a hallmark of neurodegenerative diseases such as Alzheimer's and Parkinson's. Furthermore, HPRT1P3 may play a role in the regulation of cellular energy metabolism, particularly in the context of hypoxia. As a pseudogene, HPRT1P3 may be involved in the production of ATP, the primary energy currency of the cell, through its interaction with the salvage pathway. **Clinical Significance:** The discovery of HPRT1P3 as a significantly expressed pseudogene has significant implications for our understanding of cellular stress and neurodegenerative diseases. Firstly, HPRT1P3 may serve as a biomarker for neurodegenerative diseases, such as Alzheimer's and Parkinson's, where oxidative stress and cellular energy metabolism are disrupted. Secondly, the regulation of HPRT1P3 activity may hold therapeutic potential for the treatment of these diseases. By modulating HPRT1P3 expression or activity, it may be possible to mitigate oxidative damage and promote cellular energy metabolism, thereby slowing disease progression. Finally, the study of HPRT1P3 highlights the importance of pseudogenes in cellular function and disease. As our understanding of pseudogenes continues to evolve, it is likely that we will uncover new roles for these seemingly innocuous genes in various cellular processes. In conclusion, the HPRT1P3 gene is a fascinating example of a pseudogene that has significant implications for our understanding of cellular stress and neurodegenerative diseases. Further research is needed to fully elucidate the functions and clinical significance of HPRT1P3, but the current evidence suggests that this gene is worthy of further investigation.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.