Details for: MIR137

Gene ID: 406928

Symbol: MIR137

Ensembl ID: ENSG00000284202

Description: microRNA 137

Associated with

  • Gene expression (transcription)
    (R-HSA-74160)
  • Generic transcription pathway
    (R-HSA-212436)
  • Rna polymerase ii transcription
    (R-HSA-73857)
  • Transcriptional regulation by mecp2
    (R-HSA-8986944)
  • Mirna-mediated gene silencing by mrna destabilization
    (GO:0035279)
  • Mirna-mediated post-transcriptional gene silencing
    (GO:0035195)
  • Mrna 3'-utr binding
    (GO:0003730)
  • Mrna base-pairing translational repressor activity
    (GO:1903231)
  • Negative regulation of angiogenesis
    (GO:0016525)
  • Negative regulation of blood vessel endothelial cell migration
    (GO:0043537)
  • Negative regulation of cell migration
    (GO:0030336)
  • Negative regulation of cell population proliferation
    (GO:0008285)
  • Negative regulation of g1/s transition of mitotic cell cycle
    (GO:2000134)
  • Negative regulation of neuroblast proliferation
    (GO:0007406)
  • Negative regulation of protein phosphorylation
    (GO:0001933)
  • Negative regulation of vascular associated smooth muscle cell migration
    (GO:1904753)
  • Negative regulation of vascular associated smooth muscle cell proliferation
    (GO:1904706)
  • Positive regulation of apoptotic process
    (GO:0043065)
  • Positive regulation of neuron differentiation
    (GO:0045666)
  • Risc complex
    (GO:0016442)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0032
    Cell Significance Index: -0.0400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0089
    Cell Significance Index: -0.2800
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0116
    Cell Significance Index: -0.1600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0116
    Cell Significance Index: -0.3800
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0140
    Cell Significance Index: -0.2800
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0146
    Cell Significance Index: -0.3200
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0157
    Cell Significance Index: -0.3100
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0160
    Cell Significance Index: -0.1800
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0168
    Cell Significance Index: -0.3300
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0195
    Cell Significance Index: -0.2500
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0241
    Cell Significance Index: -0.2900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** MIR137 exhibits several key characteristics that distinguish it from other microRNAs. Firstly, its expression is highly tissue-specific, with significant expression in cells of the nervous system, cardiovascular system, and immune system. Secondly, MIR137 is known to regulate a wide range of cellular processes, including cell proliferation, migration, and differentiation. Thirdly, its expression is tightly regulated by various transcriptional regulators, including MECP2, which is a key transcriptional repressor in the brain. **Pathways and Functions** MIR137 is involved in several key pathways, including: 1. **Negative regulation of angiogenesis**: MIR137 has been shown to inhibit angiogenesis, the process of new blood vessel formation, by targeting and downregulating pro-angiogenic genes. 2. **Negative regulation of cell migration**: MIR137 has been implicated in the regulation of cell migration, including the migration of endothelial cells and smooth muscle cells. 3. **Negative regulation of cell proliferation**: MIR137 has been shown to inhibit cell proliferation in various cell types, including neuronal cells and cardiac muscle cells. 4. **Positive regulation of apoptotic process**: MIR137 has been implicated in the regulation of apoptosis, or programmed cell death, in certain cell types. 5. **Regulation of neuron differentiation**: MIR137 has been shown to regulate the differentiation of neurons into mature neurons. **Clinical Significance** The dysregulation of MIR137 has been implicated in several diseases, including: 1. **Neurodegenerative diseases**: MIR137 has been shown to be downregulated in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. 2. **Cancer**: MIR137 has been implicated in the regulation of cancer cell proliferation and migration, and its downregulation has been observed in various types of cancer. 3. **Cardiovascular disease**: MIR137 has been shown to regulate angiogenesis and cell migration in the cardiovascular system, and its dysregulation has been implicated in cardiovascular disease. In conclusion, MIR137 is a small non-coding RNA molecule that plays a crucial role in regulating various cellular processes, including cell proliferation, migration, and differentiation. Its dysregulation has been implicated in several diseases, including neurodegenerative diseases, cancer, and cardiovascular disease. Further research is needed to fully understand the role of MIR137 in human disease and to explore its potential as a therapeutic target.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.