Details for: MIR33A

Gene ID: 407039

Symbol: MIR33A

Ensembl ID: ENSG00000207932

Description: microRNA 33a

Associated with

  • Apolipoprotein a-i-mediated signaling pathway
    (GO:0038027)
  • Glucose homeostasis
    (GO:0042593)
  • Mirna-mediated post-transcriptional gene silencing
    (GO:0035195)
  • Mrna 3'-utr binding
    (GO:0003730)
  • Mrna base-pairing translational repressor activity
    (GO:1903231)
  • Negative regulation of bile acid biosynthetic process
    (GO:0070858)
  • Negative regulation of bile acid secretion
    (GO:0120190)
  • Negative regulation of cholesterol efflux
    (GO:0090370)
  • Negative regulation of fatty acid biosynthetic process
    (GO:0045717)
  • Negative regulation of gene expression
    (GO:0010629)
  • Negative regulation of reverse cholesterol transport
    (GO:1903063)
  • Negative regulation of transporter activity
    (GO:0032410)
  • Positive regulation of high-density lipoprotein particle clearance
    (GO:0010983)
  • Risc complex
    (GO:0016442)
  • Triglyceride homeostasis
    (GO:0070328)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.0443
    Cell Significance Index: 0.5100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0007
    Cell Significance Index: 0.0200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0001
    Cell Significance Index: -0.0300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0004
    Cell Significance Index: 0.0000
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0028
    Cell Significance Index: -0.0300
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0029
    Cell Significance Index: -0.0400
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.0033
    Cell Significance Index: -0.0400
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0043
    Cell Significance Index: -0.0500
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0045
    Cell Significance Index: -0.0500
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0046
    Cell Significance Index: -0.0600
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0047
    Cell Significance Index: -0.0500
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0051
    Cell Significance Index: -0.0600
  • Cell Name: cerebellar neuron (CL1001611)
    Fold Change: -0.0074
    Cell Significance Index: -0.0500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **MicroRNA structure**: MIR33A is a 22-nucleotide long, single-stranded RNA molecule that is processed from a precursor RNA molecule through a complex series of steps involving the Drosha and Dicer enzymes. 2. **Target recognition**: MIR33A recognizes and binds to specific mRNA molecules, leading to their degradation or inhibition of translation, thereby regulating gene expression. 3. **Cellular expression**: MIR33A is widely expressed in various cell types, including neuronal receptor cells, smooth muscle myoblasts, lymphoid lineage restricted progenitor cells, and intestinal epithelial cells. **Pathways and Functions:** 1. **Apolipoprotein A-I-mediated signaling pathway**: MIR33A negatively regulates the apolipoprotein A-I-mediated signaling pathway, which is involved in lipid metabolism and reverse cholesterol transport. 2. **Glucose homeostasis**: MIR33A plays a role in regulating glucose homeostasis by modulating the expression of genes involved in glucose metabolism. 3. **Mirna-mediated post-transcriptional gene silencing**: MIR33A utilizes the RNA-induced silencing complex (RISC) to silence target gene expression through post-transcriptional gene silencing. 4. **Negative regulation of bile acid biosynthesis**: MIR33A negatively regulates the biosynthesis of bile acids, which are essential for lipid digestion and absorption. 5. **Negative regulation of cholesterol efflux**: MIR33A also negatively regulates cholesterol efflux, which is the process by which excess cholesterol is removed from peripheral tissues and transported to the liver for excretion. 6. **Negative regulation of fatty acid biosynthesis**: MIR33A negatively regulates the biosynthesis of fatty acids, which are essential for energy storage and lipid metabolism. **Clinical Significance:** 1. **Cardiovascular disease**: MIR33A has been implicated in the pathogenesis of cardiovascular disease, including atherosclerosis and hyperlipidemia, due to its role in regulating lipid metabolism and reverse cholesterol transport. 2. **Metabolic disorders**: MIR33A has also been linked to metabolic disorders, such as type 2 diabetes and obesity, due to its role in regulating glucose homeostasis and lipid metabolism. 3. **Cancer**: MIR33A has been shown to have a role in regulating gene expression in various types of cancer, including colorectal and breast cancer. 4. **Inflammatory diseases**: MIR33A has also been implicated in the pathogenesis of inflammatory diseases, such as rheumatoid arthritis and multiple sclerosis, due to its role in regulating immune responses. In conclusion, microRNA 33a (MIR33A) is a critical regulator of various biological processes, including lipid metabolism, glucose homeostasis, and gene expression. Its dysregulation has been implicated in the pathogenesis of cardiovascular disease, metabolic disorders, and cancer, highlighting the importance of MIR33A in human health and disease. Further research is needed to fully elucidate the mechanisms of MIR33A and its role in human biology and disease.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.