Details for: MAGEA2

Gene ID: 4101

Symbol: MAGEA2

Ensembl ID: ENSG00000268606

Description: MAGE family member A2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 4.68
    Marker Score: 2412
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 4.36
    Marker Score: 1256
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 2.3
    Marker Score: 3658
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 2.28
    Marker Score: 1261
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.52
    Marker Score: 10080
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 1.14
    Marker Score: 1269
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.13
    Marker Score: 6845
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 1.08
    Marker Score: 3222
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.05
    Marker Score: 1827
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 1.03
    Marker Score: 825
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 1.02
    Marker Score: 31474
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.97
    Marker Score: 2396
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2396
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.86
    Marker Score: 4913
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.82
    Marker Score: 745
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1269
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.44
    Marker Score: 1245
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.41
    Marker Score: 1252
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.04
    Marker Score: 1259

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Other Information

**Key characteristics:** * Gene ID: ENSG00000268606 * Ensembl ID: MAGEA2 * Protein name: Q6P448_HUMAN * Protein type: Protein * Expression: Highly expressed in eukaryotic cell, male germ cell, epithelial cell, erythrocyte, goblet cell, plasma cell, neoplastic cell, abnormal cell, germ cell, and intestinal enteroendocrine cell **Pathways and functions:** * Cellular senescence: MAGEA2 is involved in cellular senescence by promoting the expression of pro-apoptotic genes and inhibiting the expression of anti-apoptotic genes. * DNA-binding transcription factor binding: MAGEA2 binds to DNA-binding transcription factors and recruits them to specific target genes, promoting their expression. * Histone deacetylase binding: MAGEA2 binds to histone deacetylases and deacetylates specific histone residues, leading to changes in chromatin structure and gene expression. * Negative regulation of protein acetylation: MAGEA2 binds to acetyl-transferase proteins and inhibits their activity, preventing the modification of proteins and their function. * Negative regulation of protein sumoylation: MAGEA2 binds to protein sumoylation enzymes and prevents their activity, preventing the sumoylation of specific proteins. * Negative regulation of transcription by RNA polymerase II: MAGEA2 binds to the RNA polymerase II promoter region of genes involved in cellular senescence and inhibits their transcription. * Nucleus: MAGEA2 is involved in the regulation of gene expression in the nucleus, possibly by binding to DNA or RNA molecules and influencing their stability or translation. * PML body: MAGEA2 interacts with proteins of the PML body, a complex of proteins involved in cellular regulation, and modulates their activity. * Positive regulation of ubiquitin-protein transferase activity: MAGEA2 binds to ubiquitin proteins and facilitates their transfer to target proteins, leading to the degradation of those proteins. * Protein binding: MAGEA2 binds to various proteins, including other members of the MAGE family, transcription factors, and ubiquitin-protein ligases. * Protein catabolic process: MAGEA2 is involved in the regulation of the protein catabolic process, possibly by interacting with proteins involved in protein degradation. * Signal transduction by p53 class mediator: MAGEA2 binds to the p53 class mediator protein and modulates its activity, affecting cell cycle regulation and apoptosis. * Ubiquitin protein ligase binding: MAGEA2 binds to ubiquitin protein ligases and catalyzes the formation of ubiquitin-protein conjugates, leading to the degradation of target proteins. **Clinical significance:** MAGEA2 is a potential therapeutic target for various human cancers. It is frequently amplified in cancer cells and is involved in promoting cell survival, proliferation, and migration. Inhibition of MAGEA2 has been shown to inhibit cancer growth and metastasis.

Genular Protein ID: 3037095782

Symbol: Q6P448_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q6P448

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 Gene3D 2 GenomeRNAi 1 InterPro 5 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 1 Pfam 2 RefSeq 1 SAM 1 SMART 2

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 314
  • Mass: 35027
  • Checksum: 28810BE358FA3FE6
  • Sequence:
    • MPLEQRSQHC KPEEGLEARG EALGLVGAQA PATEEQQTAS SSSTLVEVTL GEVPAADSPS 
PPHSPQGASS FSTTINYTLW RQSDEGSSNQ EEEGPRMFPD LESEFQAAIS RKMVELVHFL 
LLKYQAREPV TKAEMLESVL RNCQDFFPVI FSKASEYLQL VFGIEVVEVV PISHLYILVT 
CLGLSYDGLL GDNQVMPKTG LLIIVLAIIA IEGDCAPEEK IWEELSMLEV FEGREDSVFA 
HPRKLLMQDL VQENYLEYRQ VPGSDPACYE FLWGPRALIE TSYVKVLHHT LKIGGEPHIS 
YPPLHERALR EGEE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.