Details for: MAGEA2

Gene ID: 4101

Symbol: MAGEA2

Ensembl ID: ENSG00000268606

Description: MAGE family member A2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.0101
    Cell Significance Index: 0.2600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0003
    Cell Significance Index: -0.1400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0018
    Cell Significance Index: -0.2500
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: -0.0058
    Cell Significance Index: -0.0500
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: -0.0101
    Cell Significance Index: -0.0800
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.0164
    Cell Significance Index: -0.2300
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0188
    Cell Significance Index: -0.2000
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: -0.0228
    Cell Significance Index: -0.2500
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.0234
    Cell Significance Index: -0.1300
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.0234
    Cell Significance Index: -0.2200
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.0240
    Cell Significance Index: -0.2100
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.0242
    Cell Significance Index: -0.2700
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: -0.0243
    Cell Significance Index: -0.2100
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.0254
    Cell Significance Index: -0.2700
  • Cell Name: germ cell (CL0000586)
    Fold Change: -0.0257
    Cell Significance Index: -0.1900
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.0292
    Cell Significance Index: -0.3000
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: -0.0299
    Cell Significance Index: -0.3200
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: -0.0306
    Cell Significance Index: -0.1400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** MAGEA2 is a non-coding gene that is part of the MAGE family, which is known to be involved in the regulation of various cellular processes. The gene is characterized by its ability to bind to histone deacetylases, negative regulators of protein acetylation, and transcription factors, thereby modulating gene expression. MAGEA2 is also implicated in the regulation of protein sumoylation, ubiquitin-protein transferase activity, and signal transduction by p53 class mediators. Its expression is significantly elevated in neoplastic cells, suggesting its potential role in tumorigenesis. **Pathways and Functions:** MAGEA2 is involved in several key pathways, including: 1. **Cellular Senescence**: MAGEA2 is a negative regulator of cellular senescence, a process by which cells become dormant in response to stress or DNA damage. 2. **DNA-Binding Transcription Factor Binding**: MAGEA2 binds to transcription factors, modulating gene expression and influencing cellular processes. 3. **Histone Deacetylase Binding**: MAGEA2 interacts with histone deacetylases, regulating chromatin structure and gene expression. 4. **Negative Regulation of Protein Acetylation**: MAGEA2 inhibits protein acetylation, a process that regulates protein function and cellular processes. 5. **Negative Regulation of Protein Sumoylation**: MAGEA2 also regulates protein sumoylation, a process that affects protein function and cellular processes. **Clinical Significance:** MAGEA2's expression in neoplastic cells has significant clinical implications. Its overexpression has been linked to various types of cancer, including melanoma, lung cancer, and leukemia. As a tumor suppressor gene, MAGEA2's loss or downregulation may contribute to tumorigenesis. Additionally, MAGEA2's expression in normal cells, such as epithelial cells and germ cells, highlights its role in maintaining cellular homeostasis. Furthermore, MAGEA2's involvement in cellular senescence and DNA damage response pathways suggests its potential as a therapeutic target for cancer treatment. Understanding the complex mechanisms underlying MAGEA2's function and regulation may lead to the development of novel therapeutic strategies for cancer treatment. In conclusion, MAGEA2 is a complex gene with far-reaching implications in cellular regulation and cancer. Its involvement in multiple pathways and its expression in neoplastic cells highlight its potential as a tumor suppressor gene. Further research is necessary to fully elucidate the mechanisms underlying MAGEA2's function and to explore its potential as a therapeutic target for cancer treatment.

Genular Protein ID: 3037095782

Symbol: Q6P448_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q6P448

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 Gene3D 2 InterPro 5 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 1 Pfam 2 RefSeq 1 SAM 1 SMART 2

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 314
  • Mass: 35027
  • Checksum: 28810BE358FA3FE6
  • Sequence:
    • MPLEQRSQHC KPEEGLEARG EALGLVGAQA PATEEQQTAS SSSTLVEVTL GEVPAADSPS 
PPHSPQGASS FSTTINYTLW RQSDEGSSNQ EEEGPRMFPD LESEFQAAIS RKMVELVHFL 
LLKYQAREPV TKAEMLESVL RNCQDFFPVI FSKASEYLQL VFGIEVVEVV PISHLYILVT 
CLGLSYDGLL GDNQVMPKTG LLIIVLAIIA IEGDCAPEEK IWEELSMLEV FEGREDSVFA 
HPRKLLMQDL VQENYLEYRQ VPGSDPACYE FLWGPRALIE TSYVKVLHHT LKIGGEPHIS 
YPPLHERALR EGEE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.