OR1E3 | ENSG00000142163 | NCBI 8389

Details for: OR1E3

Gene ID: 8389

Symbol: OR1E3

Ensembl ID: ENSG00000142163

Description: olfactory receptor family 1 subfamily E member 3 (gene/pseudogene)

Associated with

Expression and translocation of olfactory receptors
(R-HSA-9752946)
Olfactory signaling pathway
(R-HSA-381753)
Sensory perception
(R-HSA-9709957)
Detection of chemical stimulus involved in sensory perception of smell
(GO:0050911)
G protein-coupled receptor activity
(GO:0004930)
G protein-coupled receptor signaling pathway
(GO:0007186)
Olfactory receptor activity
(GO:0004984)
Plasma membrane
(GO:0005886)
Signal transduction
(GO:0007165)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: glutamatergic neuron (CL0000679)
Fold Change: 0.0018
Cell Significance Index: 0.0200
Cell Name: neuron (CL0000540)
Fold Change: 0.0004
Cell Significance Index: 0.0000
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.0000
Cell Significance Index: -0.0100
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.0004
Cell Significance Index: -0.0100
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.0007
Cell Significance Index: -0.0100
Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: -0.0007
Cell Significance Index: -0.0100
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -0.0007
Cell Significance Index: -0.0100
Cell Name: astrocyte (CL0000127)
Fold Change: -0.0016
Cell Significance Index: -0.0200
Cell Name: central nervous system macrophage (CL0000878)
Fold Change: -0.0022
Cell Significance Index: -0.0300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Other Information

Description

**Key Characteristics:** OR1E3 is a pseudogene, meaning it has undergone mutations that render it non-functional, yet still retains some degree of expression. This peculiarity has led researchers to investigate its potential regulatory functions. OR1E3 is primarily expressed in stromal cells and neurons, two cell types crucial for olfactory perception. Its expression patterns suggest a role in modulating the olfactory signaling pathway, which is essential for detecting chemical stimuli involved in sensory perception. **Pathways and Functions:** OR1E3's involvement in olfactory perception is mediated through its interaction with G protein-coupled receptors (GPCRs). GPCRs are a vast family of receptors that respond to a wide range of stimuli, including chemical signals. OR1E3's expression in stromal cells and neurons suggests that it may play a role in regulating the expression and translocation of olfactory receptors, thereby influencing the sensitivity and specificity of olfactory perception. The OR1E3 gene is also implicated in the detection of chemical stimuli involved in sensory perception, and its signaling pathway is linked to G protein-coupled receptor activity and G protein-coupled receptor signaling pathway. **Clinical Significance:** OR1E3's involvement in olfactory perception has significant implications for our understanding of sensory disorders. Olfactory dysfunction is a common symptom of various neurological and psychiatric conditions, including Alzheimer's disease, Parkinson's disease, and schizophrenia. OR1E3's role in modulating olfactory signaling pathways suggests that it may be a potential therapeutic target for the treatment of these conditions. Furthermore, OR1E3's expression in stromal cells and neurons highlights the importance of considering the complex interplay between different cell types in olfactory perception. In conclusion, OR1E3 is a fascinating gene that sheds light on the intricate mechanisms underlying olfactory perception. Its involvement in G protein-coupled receptor signaling pathways and its expression in stromal cells and neurons make it a valuable subject for further research. As our understanding of OR1E3 continues to evolve, it is likely to have significant implications for the diagnosis and treatment of sensory disorders. **Implications for Future Research:** 1. Investigating the regulatory functions of OR1E3 in olfactory perception. 2. Elucidating the mechanisms by which OR1E3 modulates G protein-coupled receptor signaling pathways. 3. Examining the expression patterns of OR1E3 in different tissues and cell types. 4. Exploring the potential therapeutic applications of OR1E3 in the treatment of sensory disorders. By continuing to unravel the mysteries of OR1E3, we may uncover new insights into the complex mechanisms underlying olfactory perception and develop innovative therapeutic strategies for the treatment of sensory disorders.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

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