Details for: SNORD38B

Gene ID: 94163

Symbol: SNORD38B

Ensembl ID: ENSG00000281859

Description: small nucleolar RNA, C/D box 38B

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0022
    Cell Significance Index: -0.6400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0131
    Cell Significance Index: -0.6800
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0158
    Cell Significance Index: -0.1500
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0193
    Cell Significance Index: -0.2100
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0301
    Cell Significance Index: -0.3800
  • Cell Name: cerebellar neuron (CL1001611)
    Fold Change: -0.0346
    Cell Significance Index: -0.2400
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0363
    Cell Significance Index: -0.4900
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0490
    Cell Significance Index: -0.6400
  • Cell Name: brain vascular cell (CL4023072)
    Fold Change: -0.0490
    Cell Significance Index: -0.5600
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.0509
    Cell Significance Index: -0.6000
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0516
    Cell Significance Index: -0.5900
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0527
    Cell Significance Index: -0.6200
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0532
    Cell Significance Index: -0.5700
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.0589
    Cell Significance Index: -0.7000
  • Cell Name: basket cell (CL0000118)
    Fold Change: -0.1223
    Cell Significance Index: -0.5900
  • Cell Name: serotonergic neuron (CL0000850)
    Fold Change: -0.2593
    Cell Significance Index: -0.6200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SNORD38B is a 69-nt long snoRNA, characterized by the presence of a C/D box motif (CUG or AGU) at its 5' end, which is essential for its recognition by the nucleolar machinery. Its expression profile suggests a broad range of cellular functions, including RNA processing, ribosome biogenesis, and the regulation of cellular differentiation and survival. Notably, SNORD38B is predominantly expressed in cells of the hematopoietic lineage, suggesting a potential role in the development and maintenance of immune cells. **Pathways and Functions:** SNORD38B is involved in several critical cellular processes, including: 1. **RNA processing:** SNORD38B modulates the expression of specific mRNAs by interacting with the ribonucleoprotein complex (RNP) and influencing the splicing of pre-mRNAs. 2. **Ribosome biogenesis:** SNORD38B regulates the assembly of ribosomal subunits, ensuring proper protein synthesis and cellular growth. 3. **Cellular differentiation:** SNORD38B participates in the regulation of cellular differentiation, particularly in hematopoietic cells, by modulating the expression of specific transcription factors. 4. **Apoptosis:** SNORD38B has been implicated in the regulation of apoptosis, particularly in lymphoid cells, by influencing the expression of pro-apoptotic and anti-apoptotic genes. **Clinical Significance:** The significance of SNORD38B in human disease is an area of active research. Its expression profile and functional implications suggest that SNORD38B may play a role in various conditions, including: 1. **Immune-related disorders:** SNORD38B's involvement in the regulation of immune cell development and function makes it a potential target for the treatment of immune-related diseases, such as autoimmune disorders and cancer. 2. **Cardiovascular disease:** SNORD38B's expression in cardiac cells suggests a potential role in the regulation of cardiac function and disease, including heart failure and arrhythmias. 3. **Neurological disorders:** SNORD38B's expression in neuronal cells implies a potential role in the regulation of neuronal function and disease, including neurodegenerative disorders such as Alzheimer's and Parkinson's. In conclusion, SNORD38B is a small nucleolar RNA with a complex function in cellular processes, including RNA processing, ribosome biogenesis, cellular differentiation, and apoptosis. Its expression profile and functional implications suggest a wide range of clinical significance, particularly in the context of immune-related disorders, cardiovascular disease, and neurological disorders. Further research is necessary to fully elucidate the role of SNORD38B in human disease and to explore its potential as a therapeutic target.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.