Details for: RNY1P8

Gene ID: 100873807

Symbol: RNY1P8

Ensembl ID: ENSG00000206697

Description: RNY1 pseudogene 8

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.1950
    Cell Significance Index: 2.6600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0125
    Cell Significance Index: -0.2700
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.1026
    Cell Significance Index: -1.1200
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.1140
    Cell Significance Index: -1.9200
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.1625
    Cell Significance Index: -1.6800
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: -0.1681
    Cell Significance Index: -1.6600
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: -0.2264
    Cell Significance Index: -1.7900
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.2332
    Cell Significance Index: -1.8100
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.2503
    Cell Significance Index: -1.5500
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: -0.3410
    Cell Significance Index: -1.9600
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: -0.5560
    Cell Significance Index: -1.9300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Non-coding and non-functional**: RNY1P8 is a pseudogene, meaning it does not encode a protein and does not possess functional coding potential. 2. **Wide expression in intestinal tissues**: RNY1P8 is significantly expressed in various cell types within the intestinal epithelium, including enteroendocrine cells, brush cells, and stem cells. 3. **Cell-type specific expression**: The gene's expression profile varies across different cell types, with some cells expressing RNY1P8 at higher levels than others. 4. **Regulation of cellular processes**: RNY1P8 may play a role in regulating cellular processes, such as proliferation, differentiation, and survival, particularly in the context of intestinal homeostasis. **Pathways and Functions:** While RNY1P8 does not encode a protein, its expression in various cell types suggests that it may be involved in regulating cellular processes through non-coding RNA-mediated mechanisms. Some potential pathways and functions of RNY1P8 include: 1. **Regulation of gene expression**: RNY1P8 may modulate the expression of other genes through non-coding RNA-mediated mechanisms, influencing cellular differentiation and proliferation. 2. **Cellular signaling**: RNY1P8 may participate in cellular signaling pathways, influencing cell-cell interactions and the regulation of cellular responses to environmental stimuli. 3. **Epigenetic regulation**: RNY1P8 may interact with epigenetic regulators, influencing chromatin structure and gene expression patterns. **Clinical Significance:** The expression of RNY1P8 in various cell types within the intestinal epithelium highlights its potential involvement in the development and progression of intestinal diseases. Some potential clinical implications of RNY1P8 include: 1. **Cancer diagnosis and prognosis**: RNY1P8 expression may serve as a biomarker for the detection and monitoring of intestinal cancers, particularly in the context of colon cancer. 2. **Gastrointestinal disorders**: RNY1P8 may play a role in the regulation of cellular processes in gastrointestinal disorders, such as inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS). 3. **Intestinal stem cell regulation**: RNY1P8 may influence the regulation of intestinal stem cells, impacting the maintenance of intestinal homeostasis and the development of intestinal diseases. In conclusion, the RNY1P8 gene is a unique and intriguing pseudogene with widespread expression in intestinal tissues. Further research is needed to elucidate the mechanisms by which RNY1P8 regulates cellular processes and to explore its potential clinical implications in the context of intestinal diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.