Details for: SPAG5

Gene ID: 10615

Symbol: SPAG5

Ensembl ID: ENSG00000076382

Description: sperm associated antigen 5

Associated with

Other Information

Genular Protein ID: 368267247

Symbol: SPAG5_HUMAN

Name: Sperm-associated antigen 5

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11724960

Title: Analysis of mitotic microtubule-associated proteins using mass spectrometry identifies astrin, a spindle-associated protein.

PubMed ID: 11724960

DOI: 10.1073/pnas.261371298

PubMed ID: 11549262

Title: Cloning and characterization of hMAP126, a new member of mitotic spindle-associated proteins.

PubMed ID: 11549262

DOI: 10.1006/bbrc.2001.5554

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 12356910

Title: The mitotic-spindle-associated protein astrin is essential for progression through mitosis.

PubMed ID: 12356910

DOI: 10.1242/jcs.00088

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 17664331

Title: Astrin is required for the maintenance of sister chromatid cohesion and centrosome integrity.

PubMed ID: 17664331

DOI: 10.1083/jcb.200701163

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 18361916

Title: Astrin regulates Aurora-A localization.

PubMed ID: 18361916

DOI: 10.1016/j.bbrc.2008.03.072

PubMed ID: 18055457

Title: Glycogen synthase kinase 3beta interacts with and phosphorylates the spindle-associated protein astrin.

PubMed ID: 18055457

DOI: 10.1074/jbc.m706794200

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19197158

Title: SNM1B/Apollo interacts with astrin and is required for the prophase cell cycle checkpoint.

PubMed ID: 19197158

DOI: 10.4161/cc.8.4.7791

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21402792

Title: The astrin-kinastrin/SKAP complex localizes to microtubule plus ends and facilitates chromosome alignment.

PubMed ID: 21402792

DOI: 10.1083/jcb.201008023

PubMed ID: 22965910

Title: Dynein light chain 1 and a spindle-associated adaptor promote dynein asymmetry and spindle orientation.

PubMed ID: 22965910

DOI: 10.1083/jcb.201202112

PubMed ID: 23953116

Title: Inhibition of mTORC1 by astrin and stress granules prevents apoptosis in cancer cells.

PubMed ID: 23953116

DOI: 10.1016/j.cell.2013.07.031

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24424245

Title: OSBP-related protein 8 (ORP8) interacts with Homo sapiens sperm associated antigen 5 (SPAG5) and mediates oxysterol interference of HepG2 cell cycle.

PubMed ID: 24424245

DOI: 10.1016/j.yexcr.2014.01.002

PubMed ID: 26297806

Title: Centriolar satellites assemble centrosomal microcephaly proteins to recruit CDK2 and promote centriole duplication.

PubMed ID: 26297806

DOI: 10.7554/elife.07519

PubMed ID: 27462074

Title: Nuclear mitotic apparatus (NuMA) interacts with and regulates astrin at the mitotic spindle.

PubMed ID: 27462074

DOI: 10.1074/jbc.m116.724831

Sequence Information:

  • Length: 1193
  • Mass: 134422
  • Checksum: A846DB3FE624519C
  • Sequence:
  • MWRVKKLSLS LSPSPQTGKP SMRTPLRELT LQPGALTNSG KRSPACSSLT PSLCKLGLQE 
    GSNNSSPVDF VNNKRTDLSS EHFSHSSKWL ETCQHESDEQ PLDPIPQISS TPKTSEEAVD 
    PLGNYMVKTI VLVPSPLGQQ QDMIFEARLD TMAETNSISL NGPLRTDDLV REEVAPCMGD 
    RFSEVAAVSE KPIFQESPSH LLEESPPNPC SEQLHCSKES LSSRTEAVRE DLVPSESNAF 
    LPSSVLWLSP STALAADFRV NHVDPEEEIV EHGAMEEREM RFPTHPKESE TEDQALVSSV 
    EDILSTCLTP NLVEMESQEA PGPAVEDVGR ILGSDTESWM SPLAWLEKGV NTSVMLENLR 
    QSLSLPSMLR DAAIGTTPFS TCSVGTWFTP SAPQEKSTNT SQTGLVGTKH STSETEQLLC 
    GRPPDLTALS RHDLEDNLLS SLVILEVLSR QLRDWKSQLA VPHPETQDSS TQTDTSHSGI 
    TNKLQHLKES HEMGQALQQA RNVMQSWVLI SKELISLLHL SLLHLEEDKT TVSQESRRAE 
    TLVCCCFDLL KKLRAKLQSL KAEREEARHR EEMALRGKDA AEIVLEAFCA HASQRISQLE 
    QDLASMREFR GLLKDAQTQL VGLHAKQEEL VQQTVSLTST LQQDWRSMQL DYTTWTALLS 
    RSRQLTEKLT VKSQQALQER DVAIEEKQEV SRVLEQVSAQ LEECKGQTEQ LELENSRLAT 
    DLRAQLQILA NMDSQLKELQ SQHTHCAQDL AMKDELLCQL TQSNEEQAAQ WQKEEMALKH 
    MQAELQQQQA VLAKEVRDLK ETLEFADQEN QVAHLELGQV ECQLKTTLEV LRERSLQCEN 
    LKDTVENLTA KLASTIADNQ EQDLEKTRQY SQKLGLLTEQ LQSLTLFLQT KLKEKTEQET 
    LLLSTACPPT QEHPLPNDRT FLGSILTAVA DEEPESTPVP LLGSDKSAFT RVASMVSLQP 
    AETPGMEESL AEMSIMTTEL QSLCSLLQES KEEAIRTLQR KICELQARLQ AQEEQHQEVQ 
    KAKEADIEKL NQALCLRYKN EKELQEVIQQ QNEKILEQID KSGELISLRE EVTHLTRSLR 
    RAETETKVLQ EALAGQLDSN CQPMATNWIQ EKVWLSQEVD KLRVMFLEMK NEKEKLMIKF 
    QSHRNILEEN LRRSDKELEK LDDIVQHIYK TLLSIPEVVR GCKELQGLLE FLS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.