Details for: RNU4ATAC6P

Gene ID: 106479540

Symbol: RNU4ATAC6P

Ensembl ID: ENSG00000252401

Description: RNA, U4atac small nuclear 6, pseudogene

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.0896
    Cell Significance Index: 1.1300
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.0160
    Cell Significance Index: 0.1700
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0065
    Cell Significance Index: -0.1100
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.0120
    Cell Significance Index: -0.1500
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0123
    Cell Significance Index: -0.1200
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.0140
    Cell Significance Index: -0.1500
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.0141
    Cell Significance Index: -0.1300
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.0159
    Cell Significance Index: -0.1400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0203
    Cell Significance Index: -0.4500
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.0225
    Cell Significance Index: -0.1500
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0249
    Cell Significance Index: -0.1500
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: -0.0276
    Cell Significance Index: -0.3200
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0297
    Cell Significance Index: -0.3400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** RNU4ATAC6P is a small nuclear RNA (snRNA) pseudogene, which means it is a non-coding RNA that lacks the typical coding potential of a gene. Despite this, it has been shown to be significantly expressed in multiple cell types, including those involved in the immune response. The expression of RNU4ATAC6P is not limited to immune cells, as it is also found in intestinal epithelial cells, goblet cells, and other cell types. This widespread expression suggests that RNU4ATAC6P may play a role in regulating various cellular processes, including immune responses and cell differentiation. **Pathways and Functions:** While the exact mechanisms by which RNU4ATAC6P regulates cellular processes are not yet fully understood, several pathways have been implicated in its potential functions. One possible pathway involves the regulation of RNA processing and splicing, which could impact the expression of other genes. RNU4ATAC6P may also play a role in the regulation of cell signaling pathways, such as the NF-κB pathway, which is critical for immune responses. Additionally, its expression in plasma cells and other antibody-producing cells suggests that RNU4ATAC6P may be involved in the regulation of B-cell development and function. **Clinical Significance:** The clinical significance of RNU4ATAC6P is an area of ongoing research. Given its expression in multiple cell types, including those involved in the immune response, it is possible that RNU4ATAC6P plays a role in various immune-related disorders. For example, its expression in CD4-positive T cells suggests that it may be involved in the regulation of T-cell responses, which could impact the progression of autoimmune diseases such as multiple sclerosis or type 1 diabetes. Additionally, its expression in intestinal epithelial cells and goblet cells raises the possibility that RNU4ATAC6P may be involved in the regulation of gut-associated lymphoid tissue (GALT) function, which could impact the pathogenesis of inflammatory bowel disease. In conclusion, while the exact mechanisms by which RNU4ATAC6P regulates cellular processes are not yet fully understood, its significant expression in multiple cell types and potential involvement in various biological pathways suggest that it may play a role in the regulation of immune responses and cellular differentiation. Further research is needed to fully elucidate the clinical significance of RNU4ATAC6P and its potential applications in the treatment of immune-related disorders.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.