Details for: DIPK1C

Gene ID: 125704

Gene Type:  Protein-coding  - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: DIPK1C

Ensembl ID: ENSG00000187773

Description: divergent protein kinase domain 1C

Selected Context(s):  Overall

Cell Significance Landscape

Contexts:

Associated with

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • glial cell CL0000125
    CSI 7.38
    rCSI 28.09%
    PRS 96.51
  • ependymal cell CL0000065
    CSI 6.13
    rCSI 12.43%
    PRS 93.23
  • melanocyte CL0000148
    CSI 3.96
    rCSI 2.93%
    PRS 98.19
  • Mueller cell CL0000636
    CSI 3.7
    rCSI 8.43%
    PRS 97.1
  • glioblast CL0000030
    CSI 3.41
    rCSI 5.44%
    PRS 96.8
  • forebrain radial glial cell CL0013000
    CSI 3.38
    rCSI 10.86%
    PRS 98.68
  • astrocyte of the cerebral cortex CL0002605
    CSI 3.09
    rCSI 6.93%
    PRS 96.2
  • neural progenitor cell CL0011020
    CSI 2.09
    rCSI 9.21%
    PRS 94.22

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

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Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [DIPK1C](/details-gene/125704) (divergent protein kinase domain 1C), also known as FAM69C, is a protein-coding gene located on chromosome 18q22.3. Functionally, it is annotated as a component of the endoplasmic reticulum membrane ([GO:0005789](https://www.ebi.ac.uk/QuickGO/term/GO:0005789)). Expression data highlights its significant role within the central nervous system, where it shows high specificity and abundance in various neural cell populations. **Overall**, it is most significant in [glial cell](/details-cell/CL0000125), [ependymal cell](/details-cell/CL0000065), and [melanocyte](/details-cell/CL0000148), suggesting a specialized function in these lineages. The gene was identified as part of large-scale sequencing and gene collection projects ([Link](https://doi.org/10.1038/nature03983), [Link](https://doi.org/10.1101/gr.2596504)). ## Cellular Roles and Expression Landscape The expression profile of [DIPK1C](/details-gene/125704) strongly indicates a specialized role within the nervous system and related cell types. The gene demonstrates its highest significance in a range of glial and neural cells, establishing it as a key marker for these populations. Specifically, it is a top marker in general [glial cell](/details-cell/CL0000125) populations, as well as more specialized types including [ependymal cell](/details-cell/CL0000065), retinal [Mueller cell](/details-cell/CL0000636), and [astrocyte of the cerebral cortex](/details-cell/CL0002605). Furthermore, its high significance in developmental and proliferative neural cells, such as [forebrain radial glial cell](/details-cell/CL0013000), [neural progenitor cell](/details-cell/CL0011020), and the malignant [glioblast](/details-cell/CL0000030), suggests a potential involvement in neurodevelopment, neural stem cell maintenance, or neuropathology. The notable expression in [melanocyte](/details-cell/CL0000148), a cell type derived from the embryonic neural crest, further reinforces its association with the neuroectodermal lineage. ## Pathways and Molecular Function Based on its annotation, the protein product of [DIPK1C](/details-gene/125704) is an integral component of the endoplasmic reticulum membrane ([GO:0005789](https://www.ebi.ac.uk/QuickGO/term/GO:0005789)). The gene's name, 'divergent protein kinase domain 1C,' implies it possesses enzymatic activity, likely functioning as a kinase. Its localization to the ER, a central organelle for protein folding, lipid synthesis, and calcium homeostasis, suggests that [DIPK1C](/details-gene/125704) may participate in signaling pathways that are initiated from or integrated at this site. Potential roles could include modulating the unfolded protein response (UPR), regulating ER-to-nucleus signaling, or participating in ER-associated protein degradation (ERAD) pathways, particularly within the specific neural contexts where it is highly expressed. ## Research Directions The specific expression pattern and putative kinase function of [DIPK1C](/details-gene/125704) present several avenues for future investigation, particularly concerning its role in both normal neurobiology and disease. Based on the available data, the following hypotheses can be proposed: 1. Given its high expression in various glial cell types and its localization to the ER, a key organelle in cellular stress responses, [DIPK1C](/details-gene/125704) may function as a critical regulator of glial reactivity (e.g., astrogliosis) in response to neurological injury or inflammation. 2. The significant expression of [DIPK1C](/details-gene/125704) in [neural progenitor cell](/details-cell/CL0011020) and [glioblast](/details-cell/CL0000030) suggests it could be involved in regulating the balance between self-renewal and differentiation in neural stem cells, a process that is often dysregulated in brain tumors like glioblastoma. **Key Experimental Approach:** To test the second hypothesis regarding its role in glioblastoma, a functional genomics approach could be employed. One could perform a CRISPR-Cas9-mediated knockout of [DIPK1C](/details-gene/125704) in patient-derived glioblastoma stem cell (GSC) lines. The effects of the knockout on GSC proliferation and self-renewal could be assessed using sphere-formation assays and in vivo tumorigenicity studies in immunocompromised mice. Concurrently, RNA-sequencing could be used to identify downstream signaling pathways affected by [DIPK1C](/details-gene/125704) loss, potentially revealing its molecular mechanism in maintaining the cancer stem cell phenotype. **Therapeutic Potential:** The high significance of [DIPK1C](/details-gene/125704) in [glioblast](/details-cell/CL0000030) cells, combined with its putative kinase function, makes it an attractive candidate for therapeutic intervention. Kinases are a well-established class of drug targets, and a small molecule inhibitor designed to be specific for the [DIPK1C](/details-gene/125704) kinase domain could represent a targeted strategy for glioblastoma treatment. Such an inhibitor could potentially suppress GSC proliferation and survival. Therefore, therapeutic inhibition of [DIPK1C](/details-gene/125704) warrants investigation as a potential anti-cancer strategy for this aggressive brain tumor.

Genular Protein ID: 3732175828

Symbol: DIK1C_HUMAN

Name: Protein FAM69C

UniProtKB Accession Codes:

Q0P6D2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 2 Ensembl 2 GO 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 1 SMART 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 16177791

Title: DNA sequence and analysis of human chromosome 18.

PubMed ID: 16177791

DOI: 10.1038/nature03983

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 419
  • Mass: 46420
  • Checksum: 320959B6D70EA7DF
  • Sequence:
    • MARAAGARGP AGWCRRRGRC GRGTLLAFAA WTAGWVLAAA LLLRAHPGVL SERCTDEKSR 
RILAALCQDY QGGTLAGDLC EDLCVAGELL FQRCLHYNRG KKVLQADWRG RPVVLKSKEE 
AFSSFPPLSL LEEEAGEGGQ DMPEAELLLM VAGEVKSALG LELSNSSLGP WWPGRRGPRW 
RGQLASLWAL LQQEEYVYFS LLQDLSPHVL PVLGSCGHFY AVEFLAAGSP HHRALFPLDR 
APGAPGGGQA KAISDIALSF LDMVNHFDSD FSHRLHLCDI KPENFAIRSD FTVVAIDVDM 
AFFEPKMREI LEQNCTGDED CNFFDCFSRC DLRVNKCGAQ RVNNNLQVIC DKIFRHWFSA 
PLKSSAVSFQ LQLQLQEAVQ ECADPGVPSG NTRRAASSVF WKLRQLLQAT LRELQEAEK