Details for: SNORD33

Gene ID: 26818

Symbol: SNORD33

Ensembl ID: ENSG00000199631

Description: small nucleolar RNA, C/D box 33

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0034
    Cell Significance Index: 0.0400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0005
    Cell Significance Index: -0.1500
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.0024
    Cell Significance Index: -0.0300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0035
    Cell Significance Index: -0.1800
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0052
    Cell Significance Index: -0.0700
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0064
    Cell Significance Index: -0.0700
  • Cell Name: cerebellar neuron (CL1001611)
    Fold Change: -0.0072
    Cell Significance Index: -0.0500
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0087
    Cell Significance Index: -0.1100
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0112
    Cell Significance Index: -0.1200
  • Cell Name: brain vascular cell (CL4023072)
    Fold Change: -0.0114
    Cell Significance Index: -0.1300
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0123
    Cell Significance Index: -0.1600
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0128
    Cell Significance Index: -0.1500
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0131
    Cell Significance Index: -0.1500
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.0136
    Cell Significance Index: -0.1600
  • Cell Name: basket cell (CL0000118)
    Fold Change: -0.0311
    Cell Significance Index: -0.1500
  • Cell Name: serotonergic neuron (CL0000850)
    Fold Change: -0.0669
    Cell Significance Index: -0.1600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** SNORD33 is a small nucleolar RNA (snoRNA) that belongs to the C/D box family of snoRNAs. These snoRNAs are involved in the modification of ribosomal RNA (rRNA) during the processing of ribosomes, which are essential for protein synthesis. SNORD33 is specifically expressed in cells that require high levels of protein synthesis, such as cardiac muscle cells and immune cells. The expression of SNORD33 is also notable for its restricted pattern, with significant expression in certain cell types and minimal or no expression in others. **Pathways and Functions** The primary function of SNORD33 is to regulate the processing and modification of rRNA in the nucleolus, a region of the cell where ribosome biogenesis occurs. SNORD33 interacts with other snoRNAs and proteins to guide the modification of rRNA, which is essential for the proper assembly and function of ribosomes. This process involves the addition of modifications such as pseudouridylation, methylation, and 2'-O-methylation to the rRNA, which affects the stability, folding, and translation efficiency of the ribosome. Additionally, SNORD33 has been implicated in the regulation of alternative splicing and mRNA processing, which are critical for the generation of diverse protein isoforms. SNORD33 may act as a scaffold or regulatory molecule to control the assembly of spliceosome components and the recruitment of splicing factors, thereby influencing the expression of specific genes. **Clinical Significance** The clinical significance of SNORD33 is an area of ongoing research, and its dysregulation has been implicated in various diseases. For example, alterations in SNORD33 expression have been observed in cardiac diseases, such as heart failure and cardiomyopathy, where the expression of SNORD33 is reduced. This suggests that SNORD33 may play a role in the regulation of cardiac function and the response to stress. In addition, SNORD33 has been implicated in immune disorders, such as autoimmune diseases and cancer, where the expression of SNORD33 is altered. The dysregulation of SNORD33 may contribute to the development of these diseases by disrupting normal RNA processing and modification, leading to aberrant protein expression and function. Furthermore, SNORD33 has been identified as a potential biomarker for certain diseases, such as cancer and cardiovascular disease. The expression of SNORD33 in specific cell types or tissues may provide a non-invasive means of diagnosing or monitoring these diseases. In conclusion, SNORD33 is a small nucleolar RNA that plays a critical role in the regulation of RNA processing and modification in various cell types. Its dysregulation has been implicated in various diseases, and further research is needed to fully elucidate its clinical significance and potential therapeutic applications.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.