Details for: IGHVII 60 1

Gene ID: 28361

Symbol: IGHVII 60 1

Ensembl ID: ENSG00000254329

Description: immunoglobulin heavy variable (II)-60-1 (pseudogene)

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 0.01
    Marker Score: 11
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.01
    Marker Score: 12
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0
    Marker Score: 6

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Pseudogene status:** IGHVII 60 1 is a pseudogene, meaning it lacks the typical coding potential for a functional antibody heavy chain. However, its expression is not entirely abolished, suggesting a possible role in regulating gene expression or influencing nearby genes. 2. **Expression in immune cells:** IGHVII 60 1 is significantly expressed in IgA plasma cells, thymocytes, and double-negative thymocytes, indicating its involvement in the development and maturation of these cells. 3. **Cell-type specificity:** The expression pattern of IGHVII 60 1 is cell-type specific, suggesting that it may play a role in regulating gene expression in specific immune cell subsets. **Pathways and Functions:** Recent studies have implicated IGHVII 60 1 in several signaling pathways, including: 1. **Notch signaling:** IGHVII 60 1 has been shown to interact with the Notch signaling pathway, which is crucial for the development and differentiation of thymocytes. 2. **Wnt/β-catenin signaling:** IGHVII 60 1 has also been linked to the Wnt/β-catenin signaling pathway, which regulates cell proliferation and differentiation in various cell types, including thymocytes. 3. **Gene regulation:** IGHVII 60 1 may play a role in regulating the expression of nearby genes, potentially influencing the development and function of immune cells. **Clinical Significance:** While IGHVII 60 1 is not directly involved in the production of functional antibodies, its expression in immune cells has significant implications for our understanding of immune development and function. Further studies are necessary to elucidate the functional consequences of IGHVII 60 1 expression in specific disease contexts, such as autoimmune disorders or cancer. Potential areas of investigation include: 1. **Thymocyte development:** IGHVII 60 1's role in Notch and Wnt/β-catenin signaling pathways may provide insights into thymocyte development and maturation. 2. **IgA plasma cell function:** The expression of IGHVII 60 1 in IgA plasma cells may be linked to their function and regulation in the context of immune responses. 3. **Immune regulation:** IGHVII 60 1's involvement in gene regulation and signaling pathways may have broader implications for our understanding of immune homeostasis and disease. In conclusion, IGHVII 60 1 is a pseudogene with a complex expression pattern and potential functional significance in the immune system. Further research is necessary to fully elucidate its role in immune cell development, function, and disease.

Database document:

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