Details for: IGHV3 42

Gene ID: 28427

Symbol: IGHV3 42

Ensembl ID: ENSG00000254228

Description: immunoglobulin heavy variable 3-42 (pseudogene)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.0738
    Cell Significance Index: 0.8000
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: -0.0015
    Cell Significance Index: -0.0100
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: -0.0116
    Cell Significance Index: -0.1100
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.0138
    Cell Significance Index: -0.1500
  • Cell Name: plasmablast (CL0000980)
    Fold Change: -0.0155
    Cell Significance Index: -0.1400
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0165
    Cell Significance Index: -0.1500
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0179
    Cell Significance Index: -0.2000
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.0191
    Cell Significance Index: -0.1900
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0209
    Cell Significance Index: -0.1300
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0223
    Cell Significance Index: -0.1800
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.0300
    Cell Significance Index: -0.3600
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.0321
    Cell Significance Index: -0.3500
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -0.0391
    Cell Significance Index: -0.1800
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0717
    Cell Significance Index: -0.8500
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0790
    Cell Significance Index: -0.8300
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.0955
    Cell Significance Index: -0.9800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Pseudogene status:** IGHV3-42 is considered a pseudogene, meaning it does not encode a functional protein. However, its expression in different cell types suggests that it may have non-coding roles or interact with other genes to influence immune responses. 2. **Variable cellular expressions:** IGHV3-42 is significantly expressed in B cells, plasma cells, stromal cells, IgA plasma cells, and double-negative thymocytes, indicating its involvement in various stages of immune development and function. 3. **Immunoglobulin heavy chain family:** IGHV3-42 belongs to the immunoglobulin heavy chain family, which plays a crucial role in the structure and function of antibodies. **Pathways and Functions:** 1. **Regulation of immune responses:** IGHV3-42 may influence immune responses by regulating the expression of other genes involved in immune development and function. Its expression in B cells and plasma cells suggests a role in the regulation of antibody production and immune homeostasis. 2. **Interactions with other genes:** IGHV3-42 may interact with other genes to modulate immune responses. For example, its expression in stromal cells may influence the function of immune cells in the microenvironment. 3. **Non-coding functions:** As a pseudogene, IGHV3-42 may have non-coding functions, such as regulating gene expression, modulating epigenetic marks, or influencing the activity of transcription factors. **Clinical Significance:** 1. **Immune homeostasis:** IGHV3-42's expression in various cell types suggests its involvement in maintaining immune homeostasis. Dysregulation of IGHV3-42 expression may contribute to immune disorders, such as autoimmune diseases or immunodeficiency. 2. **Cancer immunology:** IGHV3-42's expression in plasma cells and stromal cells may influence cancer immunity. Its dysregulation or aberrant expression may contribute to cancer progression or immune evasion. 3. **Therapeutic potential:** Understanding the role of IGHV3-42 in immune regulation and homeostasis may lead to the development of novel therapeutic strategies for immune-related disorders, such as cancer immunotherapy or autoimmune disease treatment. In conclusion, the IGHV3-42 gene, despite its pseudogene status, plays a significant role in regulating immune responses and influencing immune homeostasis. Further research on this gene and its cellular expressions may uncover new insights into the mechanisms of immune regulation and provide therapeutic opportunities for immune-related disorders.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.