Details for: IGHV1 68

Gene ID: 28462

Symbol: IGHV1 68

Ensembl ID: ENSG00000253703

Description: immunoglobulin heavy variable 1-68 (pseudogene)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 0.0315
    Cell Significance Index: 0.2100
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0129
    Cell Significance Index: -0.1400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0213
    Cell Significance Index: -0.3900
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0227
    Cell Significance Index: -0.2500
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0266
    Cell Significance Index: -0.2800
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0289
    Cell Significance Index: -0.2700
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0292
    Cell Significance Index: -0.3400
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0293
    Cell Significance Index: -0.3500
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0340
    Cell Significance Index: -0.3200
  • Cell Name: blood cell (CL0000081)
    Fold Change: -0.0375
    Cell Significance Index: -0.3200
  • Cell Name: plasmablast (CL0000980)
    Fold Change: -0.0391
    Cell Significance Index: -0.3600
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.0471
    Cell Significance Index: -0.4100
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.0512
    Cell Significance Index: -0.5500
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: -0.0597
    Cell Significance Index: -0.5300
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.0772
    Cell Significance Index: -0.4200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** IGHV1-68 is a pseudogene, meaning that it lacks a functional coding sequence and does not produce a protein. However, it has been found to be significantly expressed in various immune cells, suggesting that it may play a role in regulating gene expression or interacting with other molecules. The IGHV1-68 gene is located on chromosome 14q32.33, a region known for its high density of immunoglobulin genes. Notably, IGHV1-68 is expressed in a wide range of cells, including plasma cells, plasmablasts, naive B cells, and natural killer cells, which are all key players in the adaptive immune response. **Pathways and Functions:** The precise mechanisms underlying the expression of IGHV1-68 are not yet fully understood. However, several theories have been proposed: 1. **Regulation of gene expression:** IGHV1-68 may serve as a regulatory element, influencing the expression of nearby genes or interacting with transcription factors to modulate immune responses. 2. **Molecular interactions:** IGHV1-68 may interact with other molecules, such as immunoglobulins or cell surface receptors, to regulate immune cell functions or signaling pathways. 3. **Epigenetic regulation:** IGHV1-68 may be involved in epigenetic modifications, such as DNA methylation or histone modification, which could influence gene expression or chromatin structure. While the exact functions of IGHV1-68 remain unclear, its expression in various immune cells suggests that it may play a role in regulating immune responses or modulating the activity of immune cells. **Clinical Significance:** The clinical significance of IGHV1-68 is an area of active research. Some potential implications of IGHV1-68 expression include: 1. **Immunological disorders:** Abnormal expression of IGHV1-68 may contribute to the development of immunological disorders, such as autoimmune diseases or cancer. 2. **Immune surveillance:** IGHV1-68 expression may be involved in the surveillance of self-antigens or tumor antigens, influencing the activity of immune cells and the outcome of immune responses. 3. **Vaccine development:** IGHV1-68 may be a target for vaccine development, as its expression in certain immune cells could be exploited to enhance immune responses to specific antigens. In conclusion, IGHV1-68 is a pseudogene with far-reaching implications in the immune system. Further research is needed to fully understand its functions and clinical significance, but its expression in various immune cells suggests that it may play a critical role in regulating immune responses and modulating the activity of immune cells.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.