Details for: IGHD3 3

Gene ID: 28501

Symbol: IGHD3 3

Ensembl ID: ENSG00000211930

Description: immunoglobulin heavy diversity 3-3

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.0618
    Cell Significance Index: 0.6500
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 0.0122
    Cell Significance Index: 0.1100
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.0093
    Cell Significance Index: 0.1100
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.0019
    Cell Significance Index: -0.0200
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0057
    Cell Significance Index: -0.0600
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0068
    Cell Significance Index: -0.0700
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.0102
    Cell Significance Index: -0.0900
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0255
    Cell Significance Index: -0.3000
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0266
    Cell Significance Index: -0.3000
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0334
    Cell Significance Index: -0.3200
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0447
    Cell Significance Index: -0.5900
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.0734
    Cell Significance Index: -0.3900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** IGHD3 is a member of the immunoglobulin heavy chain (IgH) locus, which is responsible for encoding the heavy chains of antibodies. The gene is characterized by its unique structure, which includes a diverse region that gives rise to a wide range of heavy chain variants. This diversity is crucial for generating a diverse antibody repertoire, allowing the immune system to recognize and respond to a vast array of antigens. IGHD3 is specifically involved in the development of B cells that express IgD and IgM heavy chains, which are essential for the early stages of the immune response. **Pathways and Functions:** IGHD3 is integral to the B cell development and activation pathways. The gene's diverse region interacts with recombination activating protein 1 (RAG1) and RAG2, which facilitate the somatic recombination process that generates the diverse heavy chain repertoire. This process is essential for the development of B cells that can recognize and respond to specific antigens. Upon B cell activation, IGHD3 is involved in the regulation of gene expression, influencing the production of cytokines and the differentiation of B cells into antibody-secreting plasma cells. The gene's expression is tightly regulated by various transcription factors, including NF-κB and AP-1, which control the expression of genes involved in B cell activation and differentiation. **Clinical Significance:** Dysregulation of IGHD3 has been implicated in various B cell-related disorders, including autoimmune diseases, such as rheumatoid arthritis and lupus. Mutations in the IGHD3 gene have been associated with impaired B cell function and antibody production, leading to compromised immune responses. In addition, IGHD3 has been identified as a potential therapeutic target for the treatment of B cell malignancies, such as chronic lymphocytic leukemia (CLL) and follicular lymphoma. Modulation of IGHD3 expression and function may provide a novel approach to enhancing B cell function and improving treatment outcomes for these diseases. In conclusion, the IGHD3 gene plays a critical role in B cell development, function, and antibody production. Its unique characteristics and functions have significant implications for our understanding of B cell biology and immunology, and its dysregulation has been implicated in various B cell-related disorders. Further research into IGHD3 is essential for the development of novel therapeutic strategies for the treatment of B cell malignancies and autoimmune diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.