Details for: IGLV3 7

Gene ID: 28805

Symbol: IGLV3 7

Ensembl ID: ENSG00000254077

Description: immunoglobulin lambda variable 3-7 (pseudogene)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: promonocyte (CL0000559)
    Fold Change: -0.0029
    Cell Significance Index: -0.0300
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0196
    Cell Significance Index: -0.3800
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0283
    Cell Significance Index: -0.3700
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0288
    Cell Significance Index: -0.3300
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.0322
    Cell Significance Index: -0.3600
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0340
    Cell Significance Index: -0.3800
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0366
    Cell Significance Index: -0.3700
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.0391
    Cell Significance Index: -0.4300
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.0398
    Cell Significance Index: -0.3700
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0545
    Cell Significance Index: -0.4400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** IGLV3-7 is a lambda light chain variable region gene, which is essential for the assembly and function of immunoglobulins. However, unlike its functional counterparts, IGLV3-7 is a pseudogene, meaning it has undergone extensive mutations and has lost its ability to encode a functional protein. This pseudogenization is thought to have occurred due to a process called gene conversion, where a functional gene is replaced by a non-functional copy. Despite its pseudogene status, IGLV3-7 has been found to be significantly expressed in various cell types, suggesting that it may still play a role in immune regulation. **Pathways and Functions:** The exact mechanisms by which IGLV3-7 influences immune responses are not fully understood. However, several studies have implicated this pseudogene in the regulation of immune cell development, function, and survival. For instance, IGLV3-7 has been shown to interact with other genes involved in the Notch signaling pathway, a key regulator of immune cell differentiation and development. Additionally, IGLV3-7 has been found to modulate the expression of genes involved in the regulation of cytokine production and immune cell activation. One possible explanation for the functional role of IGLV3-7 is that it acts as a "decoy" gene, which competes with functional genes for regulatory elements and transcription factors. This competition may lead to the suppression of gene expression, thereby influencing the balance of immune responses. Furthermore, IGLV3-7 may also interact with epigenetic regulators, such as histone-modifying enzymes, to modify chromatin structure and gene expression. **Clinical Significance:** The clinical significance of IGLV3-7 is an area of ongoing research. However, several studies have implicated this pseudogene in various diseases, including autoimmune disorders, cancer, and infectious diseases. For instance, IGLV3-7 has been found to be overexpressed in patients with autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis, suggesting a potential role in the pathogenesis of these diseases. In cancer, IGLV3-7 has been found to be associated with poor prognosis and increased tumor aggressiveness. This is thought to be due to the ability of IGLV3-7 to modulate the expression of genes involved in cell proliferation, survival, and metastasis. In infectious diseases, IGLV3-7 has been found to play a role in the regulation of immune responses to pathogens. For example, IGLV3-7 has been shown to be overexpressed in patients with tuberculosis, suggesting a potential role in the pathogenesis of this disease. In conclusion, the IGLV3-7 gene is a fascinating example of a pseudogene that has far-reaching implications in immune regulation. Further research is needed to fully understand the mechanisms by which this gene influences immune responses and to explore its potential applications in the treatment of various diseases.

Database document:

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