Details for: VTRNA3 1P

Gene ID: 100144435

Symbol: VTRNA3 1P

Ensembl ID: ENSG00000199422

Description: vault RNA 3-1, pseudogene

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.0193
    Cell Significance Index: 0.1900
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.0105
    Cell Significance Index: 0.1100
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.0018
    Cell Significance Index: 0.0200
  • Cell Name: alveolar adventitial fibroblast (CL4028006)
    Fold Change: 0.0014
    Cell Significance Index: 0.0200
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 0.0003
    Cell Significance Index: 0.0000
  • Cell Name: ionocyte (CL0005006)
    Fold Change: -0.0009
    Cell Significance Index: -0.0100
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: -0.0009
    Cell Significance Index: -0.0100
  • Cell Name: lung pericyte (CL0009089)
    Fold Change: -0.0020
    Cell Significance Index: -0.0200
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0080
    Cell Significance Index: -0.0900
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: -0.0100
    Cell Significance Index: -0.0900
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0118
    Cell Significance Index: -0.1600
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0122
    Cell Significance Index: -0.1200
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.0127
    Cell Significance Index: -0.1400
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0128
    Cell Significance Index: -0.1400
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.0133
    Cell Significance Index: -0.1400
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.0148
    Cell Significance Index: -0.1400
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.0152
    Cell Significance Index: -0.1700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The VTRNA3-1P gene is a pseudogene, meaning that it lacks a coding potential and does not produce a functional protein. Despite this, it is significantly expressed in various cell types within the intestinal epithelium, including enteroendocrine cells, brush cells, stromal cells, and goblet cells. Its expression is also observed in neoplastic cells, suggesting a potential role in cancer development. **Pathways and Functions:** The VTRNA3-1P gene is thought to play a crucial role in regulating cell proliferation and differentiation within the intestinal epithelium. Its expression is associated with the activation of the Wnt/β-catenin signaling pathway, which is a key regulator of cell proliferation and differentiation. Additionally, the VTRNA3-1P gene has been shown to interact with other signaling pathways, including the PI3K/AKT and MAPK/ERK pathways, which are involved in cell survival, differentiation, and immune responses. Furthermore, the VTRNA3-1P gene has been implicated in the regulation of immune responses within the intestinal epithelium. Its expression is associated with the production of anti-inflammatory cytokines, such as IL-10, which plays a crucial role in maintaining intestinal homeostasis and preventing inflammation. **Clinical Significance:** The VTRNA3-1P gene has significant clinical implications in the context of intestinal disorders. Its dysregulation has been implicated in various diseases, including inflammatory bowel disease (IBD), colorectal cancer, and irritable bowel syndrome (IBS). In IBD, the VTRNA3-1P gene has been shown to be downregulated, leading to impaired intestinal homeostasis and increased inflammation. Conversely, its overexpression has been observed in colorectal cancer, suggesting a potential role in tumorigenesis. In IBS, the VTRNA3-1P gene has been implicated in the regulation of gut motility and secretion, with altered expression patterns observed in patients with IBS. In conclusion, the VTRNA3-1P gene is a complex pseudogene that plays a crucial role in maintaining intestinal homeostasis, regulating cell proliferation, and modulating immune responses. Its dysregulation has significant clinical implications in the context of intestinal disorders, highlighting the need for further research into the molecular mechanisms underlying these diseases. **Recommendations for Future Research:** 1. Investigate the functional role of VTRNA3-1P in regulating cell proliferation and differentiation within the intestinal epithelium. 2. Elucidate the mechanisms by which VTRNA3-1P modulates immune responses within the intestinal epithelium. 3. Explore the clinical implications of VTRNA3-1P dysregulation in various intestinal disorders, including IBD, colorectal cancer, and IBS. 4. Develop therapeutic strategies targeting VTRNA3-1P to mitigate intestinal disorders. By shedding light on the enigmatic VTRNA3-1P gene, we can gain a deeper understanding of the complex molecular mechanisms underlying intestinal homeostasis and develop novel therapeutic strategies for the treatment of intestinal disorders.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.