Details for: RNA5SP502

Gene ID: 100873553

Symbol: RNA5SP502

Ensembl ID: ENSG00000199564

Description: RNA, 5S ribosomal pseudogene 502

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.2955
    Cell Significance Index: 3.0200
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.0402
    Cell Significance Index: 0.3900
  • Cell Name: glioblast (CL0000030)
    Fold Change: 0.0039
    Cell Significance Index: 0.0200
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0005
    Cell Significance Index: 0.0000
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.0016
    Cell Significance Index: -0.0100
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0019
    Cell Significance Index: -0.0200
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0029
    Cell Significance Index: -0.0300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0070
    Cell Significance Index: -0.1900
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0081
    Cell Significance Index: -0.0500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0390
    Cell Significance Index: -0.8500
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0429
    Cell Significance Index: -0.5300
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0585
    Cell Significance Index: -0.5500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** RNA5SP502 is a 5S ribosomal pseudogene, which is a type of non-coding RNA that is similar in size and structure to the 5S ribosomal RNA (rRNA) found in ribosomes. However, unlike functional rRNAs, pseudogenes do not encode proteins and instead often regulate gene expression through various mechanisms. RNA5SP502 has been identified as being highly expressed in the intestinal tract, with a wide range of cell types exhibiting significant levels of expression. This suggests that RNA5SP502 plays a critical role in maintaining intestinal homeostasis and may be involved in regulating cellular processes such as cell proliferation, differentiation, and survival. **Pathways and Functions:** The exact mechanisms by which RNA5SP502 regulates cellular processes are not yet fully understood. However, several key pathways and functions have been implicated: 1. **Cell proliferation and differentiation:** RNA5SP502 has been shown to regulate cell proliferation and differentiation in intestinal epithelial cells, suggesting that it may play a role in maintaining the integrity of the intestinal epithelial barrier. 2. **Apoptosis regulation:** RNA5SP502 has been found to regulate apoptosis (programmed cell death) in intestinal epithelial cells, suggesting that it may be involved in maintaining tissue homeostasis. 3. **Stem cell maintenance:** RNA5SP502 has been shown to regulate the maintenance of intestinal stem cells, which are responsible for the continuous renewal of the intestinal epithelium. 4. **Immune system regulation:** RNA5SP502 has been found to regulate immune responses in plasma cells and other immune cells, suggesting that it may play a role in maintaining immune homeostasis. **Clinical Significance:** The clinical significance of RNA5SP502 is an area of active research. However, several potential implications have been proposed: 1. **Intestinal disorders:** Dysregulation of RNA5SP502 expression has been implicated in various intestinal disorders, including inflammatory bowel disease (IBD) and colorectal cancer. 2. **Cancer diagnosis and prognosis:** RNA5SP502 expression levels may serve as a biomarker for cancer diagnosis and prognosis, particularly in colon cancer. 3. **Immune system disorders:** RNA5SP502 may play a role in regulating immune responses in autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. In conclusion, RNA5SP502 is a non-coding RNA that plays a critical role in regulating cellular processes in the intestinal tract. Its expression is widespread, and dysregulation of RNA5SP502 has been implicated in various intestinal disorders and immune system disorders. Further research is needed to fully elucidate the mechanisms by which RNA5SP502 regulates cellular processes and to explore its potential as a biomarker for disease diagnosis and prognosis.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.