Details for: RNA5SP382

Gene ID: 100873637

Symbol: RNA5SP382

Ensembl ID: ENSG00000200225

Description: RNA, 5S ribosomal pseudogene 382

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.1353
    Cell Significance Index: 2.0000
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.0308
    Cell Significance Index: 0.3600
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.0278
    Cell Significance Index: 0.3600
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.0120
    Cell Significance Index: 0.0600
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.0020
    Cell Significance Index: 0.0200
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0008
    Cell Significance Index: -0.0100
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.0030
    Cell Significance Index: -0.0300
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0044
    Cell Significance Index: -0.0300
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0048
    Cell Significance Index: -0.0400
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0071
    Cell Significance Index: -0.0900
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0105
    Cell Significance Index: -0.1200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0334
    Cell Significance Index: -0.7300
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0554
    Cell Significance Index: -0.7000
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0785
    Cell Significance Index: -0.8600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Non-coding RNA**: RNA5SP382 is a pseudogene, meaning it does not encode a protein but instead regulates gene expression through RNA interference (RNAi) mechanisms. 2. **Gastrointestinal tract expression**: This gene is specifically expressed in cells within the gastrointestinal tract, including those found in the colon, small intestine, and stomach. 3. **Cell-type specificity**: RNA5SP382 is expressed in various cell types, including enteroendocrine cells, plasma cells, brush cells, stromal cells, and stem cells, suggesting its role in maintaining tissue homeostasis and regulating immune responses. 4. **Abnormal and neoplastic cell expression**: The gene's expression is also observed in abnormal and neoplastic cells, indicating its potential role in preventing cancerous transformations. **Pathways and Functions:** 1. **RNA interference (RNAi)**: RNA5SP382 is thought to regulate gene expression through RNAi mechanisms, which involve the degradation of specific mRNAs and preventing their translation into proteins. 2. **Immune regulation**: The gene's expression in immune cells, such as plasma cells and enteroendocrine cells, suggests its role in regulating immune responses and maintaining tissue homeostasis. 3. **Cell differentiation and proliferation**: RNA5SP382 may also influence cell differentiation and proliferation, as its expression is observed in stem cells and abnormal cells. 4. **Tissue homeostasis**: The gene's expression in various cell types within the gastrointestinal tract suggests its role in maintaining tissue homeostasis and preventing disease. **Clinical Significance:** 1. **Cancer prevention**: The RNA5SP382 gene's expression in abnormal and neoplastic cells suggests its potential role in preventing cancerous transformations. 2. **Immune system regulation**: The gene's expression in immune cells highlights its role in regulating immune responses and maintaining tissue homeostasis. 3. **Gastrointestinal tract disorders**: Abnormal expression of RNA5SP382 may contribute to gastrointestinal tract disorders, such as inflammatory bowel disease (IBD) and colon cancer. 4. **Therapeutic potential**: Further research on the RNA5SP382 gene may uncover its therapeutic potential in preventing or treating diseases associated with its dysregulation. In conclusion, the RNA5SP382 gene is a non-coding RNA that plays a critical role in regulating gene expression, immune responses, and tissue homeostasis within the gastrointestinal tract. Its clinical significance is underscored by its expression in abnormal and neoplastic cells, suggesting its potential role in preventing cancerous transformations. Further research is necessary to fully elucidate the RNA5SP382 gene's functions and therapeutic potential.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.