Details for: PLSCR5 AS1

Gene ID: 100874104

Symbol: PLSCR5 AS1

Ensembl ID: ENSG00000241457

Description: PLSCR5 antisense RNA 1

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.0234
    Cell Significance Index: 0.2500
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.0096
    Cell Significance Index: 0.1200
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: 0.0041
    Cell Significance Index: 0.0300
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 0.0031
    Cell Significance Index: 0.0400
  • Cell Name: adipocyte (CL0000136)
    Fold Change: 0.0015
    Cell Significance Index: 0.0200
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: 0.0004
    Cell Significance Index: 0.0100
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0031
    Cell Significance Index: -0.0400
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0032
    Cell Significance Index: -0.0400
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0043
    Cell Significance Index: -0.0600
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.0053
    Cell Significance Index: -0.0500
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0059
    Cell Significance Index: -0.0600
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0061
    Cell Significance Index: -0.0700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0062
    Cell Significance Index: -0.1400
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.0082
    Cell Significance Index: -0.0600
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.0097
    Cell Significance Index: -0.0600
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0098
    Cell Significance Index: -0.0600
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0168
    Cell Significance Index: -0.1600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Antisense RNA:** PLSCR5 AS1 is a non-coding RNA molecule that is transcribed from the antisense strand of the PLSCR5 gene. This unique characteristic allows it to regulate the expression of its host gene and other nearby genes. 2. **Tissue-specific expression:** PLSCR5 AS1 is expressed in various cell types, including intestinal epithelial cells, goblet cells, and stem cells. Its expression is also observed in neurons and neoplastic cells. 3. **Cellular stress response:** PLSCR5 AS1 is upregulated in response to cellular stress, inflammation, and cancer, suggesting its involvement in regulating cellular responses to adversity. 4. **Regulation of immune responses:** PLSCR5 AS1 has been shown to modulate immune responses, including the regulation of cytokine production and the activation of immune cells. **Pathways and Functions:** 1. **Immune regulation:** PLSCR5 AS1 regulates immune responses by modulating the expression of cytokines, chemokines, and other immune-related genes. It also interacts with immune cells, including T cells and dendritic cells. 2. **Intestinal homeostasis:** PLSCR5 AS1 maintains intestinal homeostasis by regulating the expression of genes involved in epithelial cell differentiation, goblet cell function, and stem cell maintenance. 3. **Stress response:** PLSCR5 AS1 is upregulated in response to cellular stress, including oxidative stress, inflammation, and hypoxia. It regulates the expression of genes involved in stress response, including antioxidant enzymes and heat shock proteins. 4. **Cancer regulation:** PLSCR5 AS1 has been shown to regulate cancer cell growth, invasion, and metastasis. It interacts with cancer cells, including promoting or inhibiting cell proliferation and survival. **Clinical Significance:** 1. **Intestinal diseases:** PLSCR5 AS1 dysregulation has been implicated in various intestinal diseases, including inflammatory bowel disease (IBD), irritable bowel syndrome (IBS), and colorectal cancer. 2. **Immune disorders:** PLSCR5 AS1 dysregulation has been linked to immune disorders, including autoimmune diseases, such as rheumatoid arthritis and lupus. 3. **Cancer diagnosis and therapy:** PLSCR5 AS1 can serve as a biomarker for cancer diagnosis and as a target for cancer therapy. 4. **Stress response and mental health:** PLSCR5 AS1 dysregulation has been implicated in stress response and mental health disorders, including anxiety and depression. In conclusion, PLSCR5 AS1 is a complex non-coding RNA molecule that plays a crucial role in regulating immune responses and maintaining intestinal homeostasis. Its dysregulation has been implicated in various diseases, including intestinal diseases, immune disorders, and cancer. Further research is needed to fully understand the mechanisms of PLSCR5 AS1 and its clinical significance.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.