Details for: RN7SL140P

Gene ID: 106479272

Symbol: RN7SL140P

Ensembl ID: ENSG00000266059

Description: RNA, 7SL, cytoplasmic 140, pseudogene

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.1917
    Cell Significance Index: 1.3900
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.0139
    Cell Significance Index: 0.1700
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.0036
    Cell Significance Index: 0.0400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0006
    Cell Significance Index: -0.0200
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0009
    Cell Significance Index: -0.0100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0018
    Cell Significance Index: -0.5100
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.0019
    Cell Significance Index: -0.0200
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.0024
    Cell Significance Index: -0.0200
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0028
    Cell Significance Index: -0.0300
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0047
    Cell Significance Index: -0.0500
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0056
    Cell Significance Index: -0.0700
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0128
    Cell Significance Index: -0.1400
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0133
    Cell Significance Index: -0.1200
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.0232
    Cell Significance Index: -0.1200
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0362
    Cell Significance Index: -0.4600
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0414
    Cell Significance Index: -0.4500
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.0749
    Cell Significance Index: -0.4700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** RN7SL140P is a 140-base pair RNA pseudogene that is predominantly expressed in cells of the intestinal epithelium, including enteroendocrine cells, enterocytes, goblet cells, and stem cells. Its expression is also detectable in neoplastic cells, suggesting potential involvement in carcinogenesis. Notably, RN7SL140P is not only expressed in normal tissues but also in abnormal or cancerous cells, highlighting its potential as a biomarker for disease diagnosis and monitoring. **Pathways and Functions:** The mechanisms by which RN7SL140P exerts its effects are multifaceted and not fully understood. However, several pathways have been implicated in its function: 1. **Cell signaling:** RN7SL140P has been shown to interact with various signaling molecules, including growth factors and cytokines, which are essential for cell proliferation, differentiation, and survival. 2. **Epigenetic regulation:** RN7SL140P has been found to modulate epigenetic marks, such as DNA methylation and histone modification, which are critical for gene expression and cellular differentiation. 3. **Stem cell maintenance:** RN7SL140P has been implicated in the maintenance of intestinal stem cell populations, which are essential for tissue homeostasis and regeneration. **Clinical Significance:** The clinical significance of RN7SL140P is an area of active research. Given its widespread expression in normal and neoplastic tissues, RN7SL140P holds promise as a diagnostic biomarker for various diseases, including colorectal cancer. Its involvement in cell signaling and epigenetic regulation also suggests potential therapeutic applications, such as targeting RN7SL140P for the treatment of cancer or inflammatory diseases. Furthermore, RN7SL140P may serve as a valuable tool for understanding the complex interactions between the immune system and the intestinal epithelium. Its expression in abnormal cells highlights the need for further investigation into the role of RN7SL140P in disease pathogenesis and the development of novel therapeutic strategies. In conclusion, RN7SL140P is a pseudogenic RNA that has been implicated in various cellular processes, including cell signaling, epigenetic regulation, and stem cell maintenance. Its widespread expression in normal and neoplastic tissues makes it a promising diagnostic biomarker and potential therapeutic target. Further research is necessary to fully elucidate the mechanisms by which RN7SL140P exerts its effects and to explore its clinical applications.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.