Details for: RNU4ATAC4P

Gene ID: 106479539

Symbol: RNU4ATAC4P

Ensembl ID: ENSG00000252116

Description: RNA, U4atac small nuclear 4, pseudogene

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0401
    Cell Significance Index: 1.0800
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0152
    Cell Significance Index: 0.1600
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.0112
    Cell Significance Index: 0.1100
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.0100
    Cell Significance Index: 0.0800
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.0082
    Cell Significance Index: 0.0900
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.0041
    Cell Significance Index: 0.0700
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: 0.0002
    Cell Significance Index: 0.0000
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0016
    Cell Significance Index: -0.0100
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0114
    Cell Significance Index: -0.1200
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0412
    Cell Significance Index: -0.4500
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0421
    Cell Significance Index: -0.5300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The RNU4ATAC4P pseudogene exhibits several distinct characteristics that warrant further investigation. Firstly, its widespread expression across various cell types within the intestinal epithelium indicates a possible role in maintaining tissue homeostasis. Secondly, the pseudogene's presence in neoplastic cells suggests that it may be involved in the development or progression of intestinal cancers. Furthermore, the expression of RNU4ATAC4P in intestinal crypt stem cells and transit amplifying cells highlights its potential involvement in the regulation of cell proliferation and differentiation within the intestinal epithelium. **Pathways and Functions:** The exact pathways and functions of RNU4ATAC4P are not yet fully understood. However, based on its widespread expression and association with various cellular processes, several potential mechanisms can be proposed: 1. **Regulation of cellular homeostasis:** RNU4ATAC4P may play a role in maintaining the balance of cellular processes within the intestinal epithelium, such as cell proliferation, differentiation, and apoptosis. 2. **Inhibition of tumorigenesis:** The pseudogene's presence in neoplastic cells suggests that it may act as a tumor suppressor, inhibiting the development or progression of intestinal cancers. 3. **Modulation of immune responses:** RNU4ATAC4P may also influence immune responses within the intestinal epithelium, potentially modulating the activity of immune cells or regulating the expression of immune-related genes. **Clinical Significance:** The discovery of RNU4ATAC4P has significant clinical implications, particularly in the context of intestinal cancers. Further research is needed to fully elucidate the role of this pseudogene in the development and progression of intestinal neoplasms. Potential applications of RNU4ATAC4P include: 1. **Diagnostic markers:** RNU4ATAC4P may serve as a diagnostic marker for intestinal cancers, allowing for early detection and treatment. 2. **Therapeutic targets:** The pseudogene's role in inhibiting tumorigenesis makes it a potential therapeutic target for the development of novel cancer therapies. 3. **Immunomodulatory approaches:** Understanding the modulation of immune responses by RNU4ATAC4P may lead to the development of immunomodulatory approaches for the treatment of intestinal cancers. In conclusion, the RNU4ATAC4P pseudogene is a fascinating gene that warrants further investigation into its expression patterns, pathways, and clinical implications. As an immunologist, I am excited to explore the potential mechanisms underlying the function of this pseudogene and its role in maintaining cellular homeostasis within the intestinal epithelium.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.