Details for: RNU6 148P

Gene ID: 106479631

Symbol: RNU6 148P

Ensembl ID: ENSG00000252823

Description: RNA, U6 small nuclear 148, pseudogene

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 0.6543
    Cell Significance Index: 6.2100
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.1473
    Cell Significance Index: 1.8600
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.0153
    Cell Significance Index: 0.2000
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 0.0028
    Cell Significance Index: 0.0300
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 0.0024
    Cell Significance Index: 0.0300
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0004
    Cell Significance Index: 0.0000
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0008
    Cell Significance Index: -0.0100
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0010
    Cell Significance Index: -0.0200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0036
    Cell Significance Index: -0.0400
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0785
    Cell Significance Index: -0.9900
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.1060
    Cell Significance Index: -1.1500
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.2115
    Cell Significance Index: -2.5300
  • Cell Name: granule cell (CL0000120)
    Fold Change: -0.2142
    Cell Significance Index: -2.4400
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.2294
    Cell Significance Index: -2.6300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** RNU6 148P is a pseudogene, meaning that it lacks the ability to encode a protein. However, it shares significant sequence homology with the U6 small nuclear RNA (snRNA), which is involved in the splicing of pre-mRNA. Despite its pseudogenic nature, RNU6 148P has been found to be significantly expressed in various cell types, including immune cells such as intestinal enteroendocrine cells, brush cells, and goblet cells. Its expression is also elevated in neoplastic cells and intestinal crypt stem cells, suggesting a potential role in carcinogenesis. **Pathways and Functions:** The mechanisms by which RNU6 148P exerts its effects are not fully understood. However, several studies have implicated it in the regulation of cell proliferation, differentiation, and survival. One possible mechanism involves the interaction between RNU6 148P and the U6 snRNA, which may modulate the splicing of pre-mRNA and influence the expression of genes involved in these processes. Additionally, RNU6 148P has been shown to interact with other non-coding RNAs, including microRNAs and long non-coding RNAs, which may further modulate its activity. RNU6 148P has also been implicated in the regulation of immune responses, including the activation of immune cells and the production of cytokines. Its expression is elevated in response to immune stimuli, suggesting a potential role in the regulation of immune system homeostasis. **Clinical Significance:** The clinical significance of RNU6 148P is an area of active research. Its expression has been found to be elevated in various diseases, including cancer, autoimmune disorders, and inflammatory conditions. For example, studies have shown that RNU6 148P is overexpressed in colorectal cancer, where it may contribute to tumorigenesis and metastasis. Additionally, RNU6 148P has been implicated in the pathogenesis of autoimmune disorders, including Crohn's disease and ulcerative colitis. Its expression is elevated in these conditions, where it may contribute to the dysregulation of immune responses and the development of tissue damage. In conclusion, RNU6 148P is a pseudogene with a multifaceted role in the immune system. Its expression is widespread, and it has been implicated in the regulation of cell proliferation, differentiation, and survival. Further research is needed to fully understand the mechanisms by which RNU6 148P exerts its effects and to explore its potential as a therapeutic target in various diseases. **Recommendations for Future Research:** 1. Investigate the mechanisms by which RNU6 148P interacts with other non-coding RNAs and influences the splicing of pre-mRNA. 2. Elucidate the role of RNU6 148P in the regulation of immune responses and its potential as a therapeutic target in autoimmune disorders. 3. Explore the clinical significance of RNU6 148P in various diseases, including cancer and inflammatory conditions. 4. Investigate the potential of RNU6 148P as a biomarker for disease diagnosis and prognosis. By addressing these questions, researchers can gain a deeper understanding of the complex role of RNU6 148P in the immune system and explore its potential as a therapeutic target in various diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.