Details for: SNORD24

Gene ID: 26820

Symbol: SNORD24

Ensembl ID: ENSG00000206611

Description: small nucleolar RNA, C/D box 24

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0017
    Cell Significance Index: 0.0200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0006
    Cell Significance Index: -0.1600
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.0011
    Cell Significance Index: -0.0100
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.0013
    Cell Significance Index: -0.0200
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0059
    Cell Significance Index: -0.0800
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0073
    Cell Significance Index: -0.0800
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0087
    Cell Significance Index: -0.1100
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0103
    Cell Significance Index: -0.1100
  • Cell Name: brain vascular cell (CL4023072)
    Fold Change: -0.0105
    Cell Significance Index: -0.1200
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0107
    Cell Significance Index: -0.1400
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0122
    Cell Significance Index: -0.1400
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.0127
    Cell Significance Index: -0.1500
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0128
    Cell Significance Index: -0.1500
  • Cell Name: cerebellar neuron (CL1001611)
    Fold Change: -0.0130
    Cell Significance Index: -0.0900
  • Cell Name: basket cell (CL0000118)
    Fold Change: -0.0310
    Cell Significance Index: -0.1500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Small Nucleolar RNA (snoRNA)**: SNORD24 belongs to the class of snoRNAs, which are small, non-coding RNAs involved in RNA processing and modification. 2. **C/D Box Motif**: The presence of a C/D box motif in SNORD24 is a hallmark of snoRNAs, indicating its role in guiding other RNAs during the processing and modification process. 3. **Significant Expression in Various Cell Types**: SNORD24 is expressed in a wide range of cell types, including those involved in the pancreas, nervous system, and immune system, suggesting its involvement in cellular regulation and homeostasis. 4. **Nucleolus Association**: SNORD24 is primarily localized to the nucleolus, a region involved in ribosome biogenesis and RNA processing. **Pathways and Functions:** 1. **RNA Processing and Modification**: SNORD24 is involved in the processing and modification of other RNAs, including ribosomal RNAs, tRNAs, and snoRNAs. Its C/D box motif guides these RNAs during the processing and modification process, ensuring the accuracy and efficiency of RNA metabolism. 2. **Nucleolus Biogenesis and Function**: SNORD24 plays a role in regulating nucleolus biogenesis and function, which is essential for ribosome production and cellular growth. 3. **Gene Regulation**: SNORD24 may also regulate gene expression by modulating the activity of other RNAs involved in transcriptional regulation. **Clinical Significance:** 1. **Pancreatic Disease**: SNORD24 expression has been linked to pancreatic disease, including pancreatic cancer and diabetes. Its dysregulation may contribute to the development of these diseases. 2. **Neurological Disorders**: SNORD24's involvement in the nervous system suggests its potential role in neurological disorders, such as Alzheimer's disease and Parkinson's disease. 3. **Cancer**: SNORD24's expression in neoplastic cells highlights its potential role in cancer development and progression. 4. **Immunological Disorders**: SNORD24's expression in myeloid cells and other immune cells suggests its potential role in immunological disorders, such as autoimmune diseases. In conclusion, SNORD24 is a complex gene that plays a multifaceted role in RNA processing, nucleolus biogenesis, and gene regulation. Its dysregulation may contribute to various diseases, including pancreatic disease, neurological disorders, cancer, and immunological disorders. Further research is necessary to fully elucidate the functions of SNORD24 and its potential therapeutic applications.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.