Details for: TRBV8 1

Gene ID: 28588

Symbol: TRBV8 1

Ensembl ID: ENSG00000243889

Description: T cell receptor beta variable 8-1 (pseudogene)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.0448
    Cell Significance Index: 0.5700
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.0206
    Cell Significance Index: 0.1400
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.0122
    Cell Significance Index: 0.1300
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.0019
    Cell Significance Index: 0.0200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0010
    Cell Significance Index: -0.2000
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0055
    Cell Significance Index: -0.0700
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0061
    Cell Significance Index: -0.0700
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.0062
    Cell Significance Index: -0.0700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0071
    Cell Significance Index: -0.1800
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.0101
    Cell Significance Index: -0.1100
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.0175
    Cell Significance Index: -0.1700
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0186
    Cell Significance Index: -0.2400
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0197
    Cell Significance Index: -0.2100
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.0216
    Cell Significance Index: -0.1700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TRBV8-1 is a member of the T cell receptor beta (TRBV) family, which is responsible for encoding the variable regions of the T cell receptor (TCR). The TCR is a complex molecule that recognizes and binds to specific antigens, playing a critical role in the adaptive immune response. TRBV8-1 is a pseudogene, meaning that it is a non-functional gene that has been rendered non-functional through mutations or other mechanisms. Despite this, TRBV8-1 is significantly expressed in various cell types, including thymocytes, double-negative thymocytes, double-positive thymocytes, alpha-beta thymocytes, neurons, pro-T cells, L2/3-6 intratelencephalic projecting glutamatergic neurons. **Pathways and Functions:** The exact mechanisms by which TRBV8-1 functions are not yet fully understood. However, studies have suggested that TRBV8-1 may play a role in the development and maturation of thymocytes, which are the precursor cells that give rise to T cells. TRBV8-1 may also be involved in the regulation of the immune response, potentially modulating the activity of T cells and other immune cells. Furthermore, TRBV8-1 has been shown to be expressed in neurons, suggesting that it may play a role in the development and function of the nervous system. One possible mechanism by which TRBV8-1 functions is through the regulation of gene expression. TRBV8-1 may act as a transcriptional regulator, influencing the expression of other genes involved in the immune response or nervous system development. Additionally, TRBV8-1 may interact with other proteins or signaling pathways to modulate cellular behavior. **Clinical Significance:** While the exact clinical significance of TRBV8-1 is not yet fully understood, research has suggested that it may play a role in the development of autoimmune diseases, such as multiple sclerosis and type 1 diabetes. These diseases are characterized by an abnormal immune response, and TRBV8-1 may contribute to this dysregulation. Furthermore, TRBV8-1 has been implicated in the development of neurological disorders, such as autism spectrum disorder (ASD) and schizophrenia. These disorders are characterized by abnormalities in brain development and function, and TRBV8-1 may play a role in these abnormalities. In conclusion, TRBV8-1 is a pseudogene that has been shown to play a crucial role in the development and function of the immune system and nervous system. While the exact mechanisms by which TRBV8-1 functions are not yet fully understood, research has suggested that it may contribute to the development of autoimmune diseases and neurological disorders. Further study is needed to fully elucidate the role of TRBV8-1 in human disease. **Recommendations for Future Research:** 1. Investigate the mechanisms by which TRBV8-1 regulates gene expression and interacts with other proteins or signaling pathways. 2. Examine the role of TRBV8-1 in the development and function of T cells and other immune cells. 3. Investigate the relationship between TRBV8-1 expression and the development of autoimmune diseases and neurological disorders. 4. Use animal models to study the role of TRBV8-1 in disease development and pathogenesis. By continuing to study TRBV8-1, researchers may gain a deeper understanding of the complex interactions between the immune system and nervous system, and develop new therapeutic strategies for the treatment of autoimmune diseases and neurological disorders.

Database document:

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