Details for: TRAJ7

Gene ID: 28748

Symbol: TRAJ7

Ensembl ID: ENSG00000211882

Description: T cell receptor alpha joining 7

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: T cell (CL0000084)
    Fold Change: 0.0046
    Cell Significance Index: 0.0500
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.0044
    Cell Significance Index: 0.0500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0005
    Cell Significance Index: -0.1000
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0050
    Cell Significance Index: -0.0700
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.0056
    Cell Significance Index: -0.0600
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0061
    Cell Significance Index: -0.0800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0068
    Cell Significance Index: -0.0800
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0081
    Cell Significance Index: -0.0800
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0104
    Cell Significance Index: -0.1000
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0114
    Cell Significance Index: -0.1100
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0121
    Cell Significance Index: -0.1300
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0124
    Cell Significance Index: -0.1300
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0133
    Cell Significance Index: -0.1200
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.0135
    Cell Significance Index: -0.1200
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.0139
    Cell Significance Index: -0.1200
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.0160
    Cell Significance Index: -0.0900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Location and Expression:** The TRAJ7 gene is located on chromosome 6q24.1 and is significantly expressed in B cells, CD8-positive, alpha-beta T cells, CD4-positive, alpha-beta T cells, retinal rod cells, T cells, mature alpha-beta T cells, Purkinje cells, and L2/3-6 intratelencephalic projecting glutamatergic neurons. 2. **Function:** The TRAJ7 gene is involved in the development and maturation of T cells, which are central to the adaptive immune response. It is also expressed in neurons, where it may play a role in the development and function of the nervous system. 3. **Evolutionary Conservation:** The TRAJ7 gene is conserved across species, suggesting its importance in the evolution of the immune system. **Pathways and Functions:** 1. **T Cell Receptor Signaling:** TRAJ7 is involved in the development and maturation of T cells through the T cell receptor (TCR) signaling pathway. The TCR is a complex of proteins that recognizes and binds to antigens, triggering a signaling cascade that leads to T cell activation and proliferation. 2. **Immune Cell Development:** TRAJ7 is essential for the development and maturation of T cells, which are critical for the adaptive immune response. It is also involved in the development of B cells, which are essential for the humoral immune response. 3. **Neurological Functions:** TRAJ7 is expressed in neurons, where it may play a role in the development and function of the nervous system. It is also involved in the regulation of synaptic transmission and neuronal plasticity. **Clinical Significance:** 1. **Immunological Disorders:** Mutations in the TRAJ7 gene have been associated with immunological disorders, such as autoimmune diseases and immunodeficiency syndromes. 2. **Neurological Disorders:** TRAJ7 has also been implicated in neurological disorders, such as multiple sclerosis and Alzheimer's disease. 3. **Cancer:** TRAJ7 has been found to be overexpressed in certain types of cancer, including leukemia and lymphoma. 4. **Vaccine Development:** Understanding the function and regulation of TRAJ7 may provide insights into the development of novel vaccine strategies that target the immune system. In conclusion, the TRAJ7 gene is a complex and multifunctional gene that plays a critical role in the development and function of the immune system and the nervous system. Further research is needed to fully understand the mechanisms of TRAJ7 and its clinical significance. As an expert immunologist, I believe that this gene has the potential to revolutionize our understanding of immunological and neurological disorders, and may lead to the development of novel therapeutic strategies.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.