Details for: CLEC1A

Gene ID: 51267

Gene Type:  Protein-coding  - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: CLEC1A

Ensembl ID: ENSG00000150048

Description: C-type lectin domain family 1 member A

Selected Context(s):  Overall

Cell Significance Landscape

Contexts:

Associated with

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • extravillous trophoblast CL0008036
    CSI 7.08
    rCSI 8.76%
    PRS 96.91
  • endothelial cell of placenta CL0009092
    CSI 6.23
    rCSI 30.69%
    PRS 98.05
  • retinal blood vessel endothelial cell CL0002585
    CSI 5.12
    rCSI 8.17%
    PRS 98.5
  • cardiac endothelial cell CL0010008
    CSI 3.19
    rCSI 12.88%
    PRS 98.03
  • pulmonary capillary endothelial cell CL4028001
    CSI 3.14
    rCSI 5.99%
    PRS 98.98
  • cerebral cortex endothelial cell CL1001602
    CSI 2.67
    rCSI 4.62%
    PRS 95.86
  • blood vessel endothelial cell CL0000071
    CSI 2.56
    rCSI 5.31%
    PRS 97.13
  • placental villous trophoblast CL2000060
    CSI 2.2
    rCSI 3.4%
    PRS 96.84
  • endothelial cell of pericentral hepatic sinusoid CL0019022
    CSI 2.11
    rCSI 6.49%
    PRS 98.13
  • pulmonary artery endothelial cell CL1001568
    CSI 1.86
    rCSI 2.53%
    PRS 98.68
  • type EC enteroendocrine cell CL0000577
    CSI 0.84
    rCSI 2.99%
    PRS 97.3

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

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Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [CLEC1A](/details-gene/51267), or C-type lectin domain family 1 member A, is a protein-coding gene located on chromosome 12. As a member of the C-type lectin family, it functions as a transmembrane receptor on the [plasma membrane](/details-go/GO:0005886) involved in [carbohydrate binding](/details-go/GO:0030246) and [cell surface receptor signaling](/details-go/GO:0007166). **Overall**, expression data reveals that [CLEC1A](/details-gene/51267) is a highly specific marker for placental cells, particularly [extravillous trophoblast](/details-cell/CL0008036), and is broadly significant across various endothelial cell populations, including those in the placenta, retina, and heart. This expression pattern suggests a specialized role in maternal-fetal interface biology and vascular homeostasis. ## Cellular Roles and Expression Landscape The expression profile of [CLEC1A](/details-gene/51267) indicates a highly specialized function within two primary cellular domains: the placenta and the vascular endothelium. The gene's highest significance is observed in [extravillous trophoblast](/details-cell/CL0008036) (CSI: 7.08) and [endothelial cell of placenta](/details-cell/CL0009092) (CSI: 6.23), highlighting its prominent role in placental development and function. Beyond the placenta, [CLEC1A](/details-gene/51267) demonstrates consistent and significant expression across a wide array of endothelial lineages. This includes high significance in [retinal blood vessel endothelial cell](/details-cell/CL0002585) (CSI: 5.12), [cardiac endothelial cell](/details-cell/CL0010008) (CSI: 3.19), [pulmonary capillary endothelial cell](/details-cell/CL4028001) (CSI: 3.14), and [cerebral cortex endothelial cell](/details-cell/CL1001602) (CSI: 2.67). This widespread pattern across different vascular beds suggests a conserved and fundamental function in maintaining endothelial cell identity or mediating endothelial-specific signaling processes. While early research identified its expression in dendritic cells ([Link](https://doi.org/10.1002/1521-4141(200002)30:2<697::aid-immu697>3.0.co;2-m)), the provided broad-scale expression data points more strongly to its role in trophoblastic and endothelial biology. ## Pathways and Molecular Function Functionally, [CLEC1A](/details-gene/51267) is annotated as a transmembrane protein with [transmembrane signaling receptor activity](/details-go/GO:0004888). Its C-type lectin domain confers the ability for [carbohydrate binding](/details-go/GO:0030246), which is central to its role in initiating [signal transduction](/details-go/GO:0007165) across the [plasma membrane](/details-go/GO:0005886). This molecular function is consistent with its cellular roles. In [extravillous trophoblast](/details-cell/CL0008036), [CLEC1A](/details-gene/51267) may act as a sensor for glycans in the uterine microenvironment, potentially mediating cell-cell interactions crucial for embryo implantation and immune tolerance at the maternal-fetal interface. In the diverse populations of [blood vessel endothelial cell](/details-cell/CL0000071) where it is expressed, its signaling activity could be involved in processes such as angiogenesis, inflammation, or the regulation of vascular permeability by recognizing specific circulating glycoproteins or pathogens. ## Research Directions The highly specific expression pattern of [CLEC1A](/details-gene/51267) in placental and endothelial cells opens several avenues for future investigation, particularly concerning its role in development and disease. **Proposed Hypotheses:** 1. Given its exceptional significance in [extravillous trophoblast](/details-cell/CL0008036), [CLEC1A](/details-gene/51267) likely plays a critical role in regulating trophoblast invasion and remodeling of maternal spiral arteries. Dysregulation of [CLEC1A](/details-gene/51267) function may therefore be implicated in placental disorders such as pre-eclampsia or intrauterine growth restriction. 2. The consistent expression of [CLEC1A](/details-gene/51267) across multiple endothelial beds suggests it acts as a gatekeeper of vascular homeostasis. It may function as a receptor for a yet-unidentified ligand that regulates endothelial cell survival, proliferation, or barrier function in response to physiological cues. **Experimental Approach:** To test the hypothesis regarding its role in trophoblast function, a combination of in vitro and ex vivo approaches could be employed. One could use CRISPR-Cas9 to knock out [CLEC1A](/details-gene/51267) in a human trophoblast cell line (e.g., HTR-8/SVneo). The impact of its absence on key cellular functions, such as migration and invasion, could be quantified using transwell assays. Furthermore, co-culture experiments with uterine natural killer (uNK) cells could determine if [CLEC1A](/details-gene/51267) is involved in mediating the crucial immune crosstalk required for successful placentation. **Therapeutic Potential:** The restricted expression profile of [CLEC1A](/details-gene/51267) makes it an attractive therapeutic target. Its presence on endothelial cells could be exploited for targeting pathological angiogenesis in cancer; a monoclonal antibody designed to block [CLEC1A](/details-gene/51267) function could serve as an anti-angiogenic agent. Conversely, if its deficiency is linked to placental pathologies, developing an agonistic antibody or a small molecule to enhance its signaling activity could represent a novel strategy to support placental function and fetal development.

Genular Protein ID: 368247043

Symbol: CLC1A_HUMAN

Name: C-type lectin domain family 1 member A

UniProtKB Accession Codes:

Q8NC01 Q8IUW7 Q9NZH3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 1 ExpressionAtlas 1 GO 5 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 5 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 10671229

Title: Molecular characterization of two novel C-type lectin-like receptors, one of which is selectively expressed in human dendritic cells.

PubMed ID: 10671229

DOI: 10.1002/1521-4141(200002)30:2&lt;697::aid-immu697&gt;3.0.co;2-m

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 280
  • Mass: 31952
  • Checksum: 138235ED47553F4B
  • Sequence:
    • MQAKYSSTRD MLDDDGDTTM SLHSQGSATT RHPEPRRTEH RAPSSTWRPV ALTLLTLCLV 
LLIGLAALGL LFFQYYQLSN TGQDTISQME ERLGNTSQEL QSLQVQNIKL AGSLQHVAEK 
LCRELYNKAG AHRCSPCTEQ WKWHGDNCYQ FYKDSKSWED CKYFCLSENS TMLKINKQED 
LEFAASQSYS EFFYSYWTGL LRPDSGKAWL WMDGTPFTSE LFHIIIDVTS PRSRDCVAIL 
NGMIFSKDCK ELKRCVCERR AGMVKPESLH VPPETLGEGD

Genular Protein ID: 660367467

Symbol: B4DV89_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DV89

Database IDs:

ARBA 1 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 3 Gene3D 1 InterPro 5 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 1 Pfam 1 RefSeq 1 SAM 1 SMART 1 SMR 1 SUPFAM 1

Sequence Information:

  • Length: 188
  • Mass: 21739
  • Checksum: B04C4E8517544941
  • Sequence:
    • MQAKYSSTRD MLDDDGDTTM SLHSQASATT RHPEPRRTAH RCSPCTEQWK WHGDNCYQFY 
KDSKSWEDCK YFCLSENSTM LKINKQEDLE FAASQSYSEF FYSYWTGLLR PDSGKAWLWM 
DGTPFTSELF HIIIDVTSPR SRDCVAILNG MIFSKDCKEL KRCVCERRAG MVKPESLHVP 
PETLGEGD

Genular Protein ID: 555697878

Symbol: E9PFB4_HUMAN

Name: N/A

UniProtKB Accession Codes:

E9PFB4

Database IDs:

ARBA 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 Gene3D 1 GeneTree 1 HGNC 1 InterPro 5 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 2 Pfam 1 Proteomes 2 ProteomicsDB 2 RefSeq 1 SAM 1 SMART 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

Sequence Information:

  • Length: 247
  • Mass: 28410
  • Checksum: B4CAD1B8B86420A8
  • Sequence:
    • MQAKYSSTRD MLDDDGDTTM SLHSQGSATT RHPEPRRTVF QYYQLSNTGQ DTISQMEERL 
GNTSQELQSL QVQNIKLAGS LQHVAEKLCR ELYNKAGAHR CSPCTEQWKW HGDNCYQFYK 
DSKSWEDCKY FCLSENSTML KINKQEDLEF AASQSYSEFF YSYWTGLLRP DSGKAWLWMD 
GTPFTSELFH IIIDVTSPRS RDCVAILNGM IFSKDCKELK RCVCERRAGM VKPESLHVPP 
ETLGEGD

Genular Protein ID: 1564531986

Symbol: E7ESV9_HUMAN

Name: N/A

UniProtKB Accession Codes:

E7ESV9

Database IDs:

ARBA 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 Gene3D 1 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 5 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 2 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 1 SMART 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

Sequence Information:

  • Length: 188
  • Mass: 21725
  • Checksum: B7ABD2E6D37016E1
  • Sequence:
    • MQAKYSSTRD MLDDDGDTTM SLHSQGSATT RHPEPRRTAH RCSPCTEQWK WHGDNCYQFY 
KDSKSWEDCK YFCLSENSTM LKINKQEDLE FAASQSYSEF FYSYWTGLLR PDSGKAWLWM 
DGTPFTSELF HIIIDVTSPR SRDCVAILNG MIFSKDCKEL KRCVCERRAG MVKPESLHVP 
PETLGEGD

Genular Protein ID: 3885159901

Symbol: B3KRP6_HUMAN

Name: N/A

UniProtKB Accession Codes:

B3KRP6

Database IDs:

ARBA 1 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 4 GO 3 Gene3D 1 InterPro 5 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 1 Pfam 1 RefSeq 1 SAM 1 SMART 1 SMR 1 SUPFAM 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 247
  • Mass: 28424
  • Checksum: CF4E89FD3C3DE352
  • Sequence:
    • MQAKYSSTRD MLDDDGDTTM SLHSQASATT RHPEPRRTVF QYYQLSNTGQ DTISQMEERL 
GNTSQELQSL QVQNIKLAGS LQHVAEKLCR ELYNKAGAHR CSPCTEQWKW HGDNCYQFYK 
DSKSWEDCKY FCLSENSTML KINKQEDLEF AASQSYSEFF YSYWTGLLRP DSGKAWLWMD 
GTPFTSELFH IIIDVTSPRS RDCVAILNGM IFSKDCKELK RCVCERRAGM VKPESLHVPP 
ETLGEGD