Details for: RPL23AP1

Gene ID: 6148

Symbol: RPL23AP1

Ensembl ID: ENSG00000239257

Description: ribosomal protein L23a pseudogene 1

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 0.0522
    Cell Significance Index: 0.4600
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 0.0348
    Cell Significance Index: 0.3900
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: -0.0027
    Cell Significance Index: -0.0300
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.0236
    Cell Significance Index: -0.3000
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0236
    Cell Significance Index: -0.2900
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0463
    Cell Significance Index: -0.5500
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.0493
    Cell Significance Index: -0.4100
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.0505
    Cell Significance Index: -0.6300
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.0578
    Cell Significance Index: -0.7200
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.0758
    Cell Significance Index: -0.5800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** RPL23AP1 is a pseudogene, meaning that it has undergone genetic drift and has lost its functional coding capacity. However, it has retained some regulatory elements, such as promoters and enhancers, which allow it to interact with nearby genes and influence their expression. The expression of RPL23AP1 is highly specific to retinal cells, suggesting that it plays a role in the development and maintenance of retinal function. Notably, RPL23AP1 is expressed in both light-sensitive (ON) and dark-sensitive (OFF) retinal ganglion cells, indicating that it may have a role in the regulation of retinal circuitry. **Pathways and Functions** The exact mechanisms by which RPL23AP1 regulates retinal function are not fully understood. However, several key pathways are thought to be involved: 1. **Cell signaling**: RPL23AP1 may interact with nearby genes to modulate cell signaling pathways that regulate retinal development and function. 2. **Gene expression regulation**: RPL23AP1 may influence the expression of nearby genes involved in retinal development, maintenance, and function. 3. **Epigenetic regulation**: RPL23AP1 may interact with epigenetic regulators to modulate the expression of nearby genes. **Clinical Significance** The discovery of RPL23AP1 as a pseudogene with functional implications in the retina highlights the complexity of gene regulation in this tissue. Further study of RPL23AP1 may provide insights into the molecular mechanisms underlying retinal development and function, as well as the pathogenesis of retinal diseases. Specifically, RPL23AP1 may have implications for: 1. **Retinal development**: Understanding the role of RPL23AP1 in retinal development may provide insights into the causes of congenital retinal abnormalities. 2. **Retinal disease**: RPL23AP1 may play a role in the pathogenesis of retinal diseases, such as retinitis pigmentosa, which is characterized by progressive retinal degeneration. 3. **Gene therapy**: RPL23AP1 may serve as a target for gene therapy interventions aimed at restoring retinal function in patients with retinal diseases. In conclusion, the RPL23AP1 gene is a pseudogene with significant functional implications in the retina. Further study of this gene may provide insights into the molecular mechanisms underlying retinal development and function, as well as the pathogenesis of retinal diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.