Details for: RNU7 6P

Gene ID: 100147749

Symbol: RNU7 6P

Ensembl ID: ENSG00000252654

Description: RNA, U7 small nuclear 6 pseudogene

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.6646
    Cell Significance Index: 7.2800
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 0.0096
    Cell Significance Index: 0.1100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0040
    Cell Significance Index: 0.0900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0003
    Cell Significance Index: -0.0900
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0034
    Cell Significance Index: -0.0500
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0055
    Cell Significance Index: -0.0600
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0055
    Cell Significance Index: -0.0700
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0065
    Cell Significance Index: -0.0700
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0073
    Cell Significance Index: -0.0900
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0084
    Cell Significance Index: -0.1000
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0091
    Cell Significance Index: -0.1100
  • Cell Name: brain vascular cell (CL4023072)
    Fold Change: -0.0096
    Cell Significance Index: -0.1100
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.0132
    Cell Significance Index: -0.1100
  • Cell Name: cerebellar neuron (CL1001611)
    Fold Change: -0.0141
    Cell Significance Index: -0.1000
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.0144
    Cell Significance Index: -0.1100
  • Cell Name: basket cell (CL0000118)
    Fold Change: -0.0249
    Cell Significance Index: -0.1200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Pseudogene status:** RNU7 6P is a pseudogene, meaning that it lacks a functional coding sequence. Despite this, it has been found to be expressed in a significant number of cells, indicating that it may have non-coding functions or be involved in regulating gene expression. 2. **Widespread expression:** RNU7 6P is expressed in a diverse range of cells within the intestinal epithelium, including enteroendocrine cells, plasma cells, brush cells, stromal cells, intestinal epithelial cells, goblet cells, and neoplastic cells. 3. **Cell type specificity:** The expression of RNU7 6P is cell-type specific, suggesting that it may play a role in maintaining the integrity and function of specific cell types within the intestinal epithelium. **Pathways and Functions:** 1. **Non-coding RNA regulation:** RNU7 6P may play a role in regulating gene expression through non-coding RNA mechanisms, such as microRNA-mediated repression or long non-coding RNA-mediated regulation. 2. **Cell differentiation and proliferation:** The expression of RNU7 6P in intestinal epithelial cells and stem cells suggests that it may be involved in regulating cell differentiation and proliferation. 3. **Cell survival and apoptosis:** The expression of RNU7 6P in neoplastic cells suggests that it may be involved in regulating cell survival and apoptosis, potentially contributing to tumorigenesis. 4. **Intestinal homeostasis:** The widespread expression of RNU7 6P in various cell types within the intestinal epithelium suggests that it may play a role in maintaining intestinal homeostasis and preventing disease. **Clinical Significance:** 1. **Intestinal disorders:** The expression of RNU7 6P in intestinal disorders, such as inflammatory bowel disease (IBD) and colorectal cancer, suggests that it may be involved in the pathogenesis of these diseases. 2. **Cancer diagnosis and treatment:** The expression of RNU7 6P in neoplastic cells may serve as a diagnostic biomarker for cancer, allowing for early detection and treatment. 3. **Therapeutic targets:** The involvement of RNU7 6P in cell differentiation, proliferation, and survival suggests that it may be a therapeutic target for the treatment of intestinal disorders and cancer. 4. **Immunological implications:** The expression of RNU7 6P in plasma cells and other immune cells suggests that it may play a role in regulating the immune response and preventing autoimmune disease. In conclusion, RNU7 6P is a pseudogene that has been found to be expressed in a wide range of cell types within the intestinal epithelium. Its non-coding RNA regulation, involvement in cell differentiation, proliferation, and survival, and potential role in maintaining intestinal homeostasis make it a fascinating gene with far-reaching implications in intestinal cell biology. Further research is needed to fully elucidate the functions and clinical significance of RNU7 6P.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.