Details for: RNA5SP299

Gene ID: 100873574

Symbol: RNA5SP299

Ensembl ID: ENSG00000212505

Description: RNA, 5S ribosomal pseudogene 299

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 0.4304
    Cell Significance Index: 4.0900
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.0747
    Cell Significance Index: 0.4000
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0035
    Cell Significance Index: -0.0400
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0184
    Cell Significance Index: -0.3200
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0250
    Cell Significance Index: -0.2400
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.0275
    Cell Significance Index: -0.2500
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0276
    Cell Significance Index: -0.3400
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0310
    Cell Significance Index: -0.3200
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0325
    Cell Significance Index: -0.3000
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.0371
    Cell Significance Index: -0.2900
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: -0.0458
    Cell Significance Index: -0.3600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0929
    Cell Significance Index: -2.0300
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.1502
    Cell Significance Index: -1.7200
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.1643
    Cell Significance Index: -2.0700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** RNA5SP299 is a 5S ribosomal pseudogene, which means that it is a non-coding sequence that is similar in structure to the 5S ribosomal RNA (rRNA) genes. However, unlike traditional rRNA genes, RNA5SP299 does not encode a functional rRNA molecule. Instead, it is thought to be involved in regulating transcriptional processes or interacting with other non-coding RNAs. The fact that RNA5SP299 is significantly expressed in immune cells and intestinal tissues suggests that it may play a role in regulating immune responses or maintaining intestinal homeostasis. **Pathways and Functions:** While the exact mechanisms by which RNA5SP299 regulates cellular processes are not yet fully understood, several pathways and functions are proposed based on its expression patterns and functional characteristics. These include: 1. **Transcriptional regulation:** RNA5SP299 may interact with transcription factors or other non-coding RNAs to regulate the expression of genes involved in immune responses or intestinal homeostasis. 2. **RNA processing:** RNA5SP299 may influence the processing of other non-coding RNAs, such as microRNAs or long non-coding RNAs, which are involved in regulating gene expression. 3. **Cellular differentiation:** RNA5SP299 may play a role in regulating cellular differentiation in immune cells, such as thymocytes, or in intestinal epithelial cells. 4. **Apoptosis regulation:** RNA5SP299 may be involved in regulating apoptosis (programmed cell death) in neoplastic cells or other cell types. **Clinical Significance:** The expression of RNA5SP299 in various disease states, including cancer, highlights its potential as a biomarker or therapeutic target. For example: 1. **Cancer diagnosis:** RNA5SP299 may be used as a diagnostic marker for certain types of cancer, such as colon cancer, where it is overexpressed in neoplastic cells. 2. **Immunotherapy:** RNA5SP299 may be targeted by immunotherapies aimed at modulating immune responses in cancer patients. 3. **Intestinal diseases:** RNA5SP299 may be involved in the pathogenesis of intestinal diseases, such as inflammatory bowel disease (IBD), and may be used as a therapeutic target to regulate intestinal homeostasis. In conclusion, RNA5SP299 is a pseudogene with widespread expression in immune cells and intestinal tissues, suggesting that it plays a role in regulating cellular processes beyond its traditional role as a pseudogene. Further research is needed to fully understand the mechanisms by which RNA5SP299 regulates cellular processes and its clinical significance in various disease states.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.