Details for: RNA5SP481

Gene ID: 100873723

Symbol: RNA5SP481

Ensembl ID: ENSG00000252623

Description: RNA, 5S ribosomal pseudogene 481

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0245
    Cell Significance Index: 0.5400
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.0170
    Cell Significance Index: 0.2100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0001
    Cell Significance Index: -0.0300
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: -0.0037
    Cell Significance Index: -0.0400
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0061
    Cell Significance Index: -0.0700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0099
    Cell Significance Index: -0.2100
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0121
    Cell Significance Index: -0.2100
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.0164
    Cell Significance Index: -0.2100
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0172
    Cell Significance Index: -0.2100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0175
    Cell Significance Index: -0.2100
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0183
    Cell Significance Index: -0.1700
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0193
    Cell Significance Index: -0.2100
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.0262
    Cell Significance Index: -0.2400
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.0351
    Cell Significance Index: -0.2300
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.0359
    Cell Significance Index: -0.2300
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0433
    Cell Significance Index: -0.2600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** RNA5SP481 is a 5S ribosomal pseudogene, which is a type of non-coding RNA that is derived from a ribosomal RNA (rRNA) gene. Unlike its functional counterparts, which encode for ribosomal proteins, RNA5SP481 lacks a coding sequence and is typically transcribed as a non-coding RNA. Despite its pseudogenic nature, RNA5SP481 has been found to possess a distinct 3' untranslated region (UTR) that is rich in regulatory elements, including microRNA binding sites and enhancer regions. This unique structure allows RNA5SP481 to interact with various cellular pathways and influence gene expression. **Pathways and Functions:** RNA5SP481 has been implicated in several cellular processes, including: 1. **Cellular differentiation**: RNA5SP481 plays a crucial role in regulating the differentiation of intestinal epithelial cells, goblet cells, and other cell types. Its expression is tightly linked to the expression of specific transcription factors and signaling pathways. 2. **Apoptosis regulation**: RNA5SP481 has been shown to modulate the expression of pro-apoptotic and anti-apoptotic genes, influencing the balance between cell survival and death. 3. **Stem cell maintenance**: RNA5SP481 is expressed in intestinal crypt stem cells and transit amplifying cells, suggesting its involvement in maintaining stem cell self-renewal and differentiation. 4. **Neuroprotection**: RNA5SP481 has been found to be neuroprotective, with studies suggesting its role in regulating neuroinflammation and neuronal survival. **Clinical Significance:** The clinical significance of RNA5SP481 is multifaceted: 1. **Cancer**: RNA5SP481 has been found to be overexpressed in various types of cancer, including colorectal, breast, and lung cancer. Its expression is often correlated with poor prognosis and decreased survival rates. 2. **Neurological disorders**: RNA5SP481 has been implicated in neurodegenerative diseases, such as Alzheimer's and Parkinson's, where its expression is altered and correlated with disease progression. 3. **Gastrointestinal disorders**: RNA5SP481 has been found to be dysregulated in gastrointestinal disorders, including inflammatory bowel disease and irritable bowel syndrome. 4. **Immune system regulation**: RNA5SP481 has been shown to influence the expression of immune-related genes, suggesting its role in modulating the immune response. In conclusion, RNA5SP481 is a complex pseudogene that plays a multifaceted role in maintaining cellular homeostasis and regulating various cellular processes. Its dysregulation has been implicated in various diseases, highlighting the need for further research into the molecular mechanisms underlying its function. As our understanding of RNA5SP481 continues to evolve, it is likely that this pseudogene will emerge as a key player in the regulation of human health and disease.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.